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    CAPN3 calpain 3 [ Propithecus coquereli (Coquerel's sifaka) ]

    Gene ID: 105814391, updated on 13-Mar-2024

    Summary

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    Gene symbol
    CAPN3
    Gene description
    calpain 3
    See related
    Ensembl:ENSPCOG00000017472
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Propithecus coquereli
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Indriidae; Propithecus
    Orthologs
    human mouse all
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    Genomic context

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    See CAPN3 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    100 current Pcoq_1.0 (GCF_000956105.1) Unplaced Scaffold NW_012148618.1 (13443796..13494772)

    NW_012148618.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 87A Neighboring gene glucosidase alpha, neutral C Neighboring gene zinc finger protein 106 Neighboring gene synaptosome associated protein 23

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_012148618.1 Unplaced Scaffold Reference Pcoq_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calpain-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Propithecus coquereli Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Pcoq_1.0 Primary Assembly

    Genomic

    1. NW_012148618.1 Reference Pcoq_1.0 Primary Assembly

      Range
      13443796..13494772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012649332.1 → XP_012504786.1  calpain-3 isoform X1

      UniProtKB/TrEMBL
      A0A2K6FD15, A0A2K6FD44
      Related
      ENSPCOP00000011883.1, ENSPCOT00000022474.1
      Conserved Domains (5) summary
      cd00051
      Location:697 → 751
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00648
      Location:75 → 415
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:429 → 579
      Calpain_III; Calpain large subunit, domain III
      pfam16648
      Location:583 → 653
      Calpain_u2; Unstructured region on Calpain-3
      cl08302
      Location:728 → 817
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. XM_012649333.1 → XP_012504787.1  calpain-3 isoform X2

      UniProtKB/TrEMBL
      A0A2K6FD15, A0A2K6FD43
      Related
      ENSPCOP00000011884.1, ENSPCOT00000022475.1
      Conserved Domains (5) summary
      cd00051
      Location:691 → 745
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00648
      Location:75 → 415
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:429 → 579
      Calpain_III; Calpain large subunit, domain III
      pfam16648
      Location:583 → 647
      Calpain_u2; Unstructured region on Calpain-3
      cl08302
      Location:722 → 811
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. XM_012649335.1 → XP_012504789.1  calpain-3 isoform X4

      UniProtKB/TrEMBL
      A0A2K6FD07, A0A2K6FD15
      Related
      ENSPCOP00000011886.1, ENSPCOT00000022477.1
      Conserved Domains (4) summary
      cd00051
      Location:605 → 659
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00648
      Location:75 → 367
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:381 → 531
      Calpain_III; Calpain large subunit, domain III
      cl08302
      Location:636 → 725
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. XM_012649334.1 → XP_012504788.1  calpain-3 isoform X3

      Conserved Domains (4) summary
      cd00051
      Location:185 → 239
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01067
      Location:1 → 67
      Calpain_III; Calpain large subunit, domain III
      pfam16648
      Location:71 → 141
      Calpain_u2; Unstructured region on Calpain-3
      cl08302
      Location:141 → 210
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version

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