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    MITF melanocyte inducing transcription factor [ Bison bison bison ]

    Gene ID: 105004395, updated on 13-Mar-2024

    Summary

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    Gene symbol
    MITF
    Gene description
    melanocyte inducing transcription factor
    See related
    Ensembl:ENSBBBG00000009019
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bison bison bison (sub-species: bison)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bison
    Orthologs
    human mouse all
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    Genomic context

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    See MITF in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    100 current Bison_UMD1.0 (GCF_000754665.1) Unplaced Scaffold NW_011495035.1 (816303..1044759)

    NW_011495035.1Genomic Context describing neighboring genes Neighboring gene FERM domain containing 4B Neighboring gene ras-related protein Rab-2B pseudogene Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene uncharacterized LOC105004396

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_011495035.1 Unplaced Scaffold Reference Bison_UMD1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microphthalmia-associated transcription factor
    Names
    melanogenesis associated transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Bison bison bison Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Bison_UMD1.0 Primary Assembly

    Genomic

    1. NW_011495035.1 Reference Bison_UMD1.0 Primary Assembly

      Range
      816303..1044759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010861986.1 → XP_010860288.1  microphthalmia-associated transcription factor isoform X2

      See identical proteins and their annotated locations for XP_010860288.1

      UniProtKB/TrEMBL
      A0A6P3J141
      Related
      ENSBBBP00000016252.1, ENSBBBT00000033171.1
      Conserved Domains (3) summary
      cd18926
      Location:294 → 397
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:391 → 510
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:56 → 194
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    2. XM_010861987.1 → XP_010860289.1  microphthalmia-associated transcription factor isoform X3

      See identical proteins and their annotated locations for XP_010860289.1

      UniProtKB/TrEMBL
      A0A6P3J6R9
      Conserved Domains (3) summary
      cd18926
      Location:293 → 396
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:390 → 509
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:55 → 193
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    3. XM_010861991.1 → XP_010860293.1  microphthalmia-associated transcription factor isoform X7

      See identical proteins and their annotated locations for XP_010860293.1

      UniProtKB/TrEMBL
      A0A6P3J143
      Related
      ENSBBBP00000027783.1, ENSBBBT00000027834.1
      Conserved Domains (3) summary
      cd00083
      Location:251 → 311
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam11851
      Location:339 → 458
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 142
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    4. XM_010861985.1 → XP_010860287.1  microphthalmia-associated transcription factor isoform X1

      UniProtKB/TrEMBL
      A0A6P3J8J9
      Conserved Domains (3) summary
      cd00083
      Location:319 → 379
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam11851
      Location:407 → 520
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:72 → 210
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    5. XM_010861990.1 → XP_010860292.1  microphthalmia-associated transcription factor isoform X6

      UniProtKB/TrEMBL
      A0A6P3J8K3
      Conserved Domains (3) summary
      cd00083
      Location:263 → 323
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam11851
      Location:351 → 464
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:72 → 154
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    6. XM_010861988.1 → XP_010860290.1  microphthalmia-associated transcription factor isoform X4

      See identical proteins and their annotated locations for XP_010860290.1

      UniProtKB/TrEMBL
      A0A6P3JA81
      Related
      ENSBBBP00000027779.1, ENSBBBT00000033155.1
      Conserved Domains (3) summary
      cd18926
      Location:278 → 381
      bHLHzip_MITF; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins
      pfam11851
      Location:375 → 494
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:40 → 178
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

    7. XM_010861989.1 → XP_010860291.1  microphthalmia-associated transcription factor isoform X5

      See identical proteins and their annotated locations for XP_010860291.1

      UniProtKB/TrEMBL
      A0A6P3J133
      Conserved Domains (3) summary
      cd00083
      Location:286 → 346
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
      pfam11851
      Location:374 → 487
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:39 → 177
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
    Nucleotide Protein
    Heading Accession and Version

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