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    ZNF511-PRAP1 ZNF511-PRAP1 readthrough [ Homo sapiens (human) ]

    Gene ID: 104326056, updated on 10-Oct-2023

    Summary

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    Official Symbol
    ZNF511-PRAP1provided by HGNC
    Official Full Name
    ZNF511-PRAP1 readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:38088
    See related
    Ensembl:ENSG00000283496 AllianceGenome:HGNC:38088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This locus represents naturally occurring readthrough transcription between the neighboring ZNF511 (zinc finger protein 511) and PRAP1 (proline-rich acidic protein 1) genes on chromosome 10. The putative readthrough transcript may encode a fusion protein that shares sequence identity with each individual gene product and may be involved in the regulation of gene promoters, particularly those found on transfected plasmids. [provided by RefSeq, Apr 2017]
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    Genomic context

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    See ZNF511-PRAP1 in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133308914..133352683)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134263351..134307799)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135122418..135166187)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135075828-135076804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135084013-135084769 Neighboring gene ADAM metallopeptidase domain 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135087865-135088514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135089815-135090462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4242 Neighboring gene tubulin gamma complex component 2 Neighboring gene uncharacterized LOC124902562 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:135106330-135107529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4243 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135122506-135123201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135127847-135128348 Neighboring gene zinc finger protein 511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135148655-135149330 Neighboring gene calcyon neuron specific vesicular protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160243-135160902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160903-135161562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135161563-135162222 Neighboring gene BANF1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135169540-135170274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2975 Neighboring gene proline rich acidic protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2976 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:135172784-135172946 Neighboring gene fucose mutarotase Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene microRNA 3944

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. Qiu GH, et al. Mol Ther, 2011 Aug. PMID 21540836, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    General protein information

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    Preferred Names
    ZNF511-PRAP1 readthrough

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396060.1 → NP_001382989.1  ZNF511-PRAP1 readthrough

      Status: VALIDATED

      Source sequence(s)
      AL360181
      UniProtKB/TrEMBL
      H7BY64
      Related
      ENSP00000357542.5, ENST00000368554.8
      Conserved Domains (1) summary
      sd00020
      Location:109 → 130
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      133308914..133352683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      134263351..134307799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials