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    CBL Cbl proto-oncogene [ Haliaeetus albicilla (white-tailed eagle) ]

    Gene ID: 104313808, updated on 3-Aug-2024

    Summary

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    Gene symbol
    CBL
    Gene description
    Cbl proto-oncogene
    Locus tag
    N329_03216
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Haliaeetus albicilla
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Telluraves; Accipitrimorphae; Accipitriformes; Accipitridae; Accipitrinae; Haliaeetus
    Orthologs
    human mouse all
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    Genomic context

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    See CBL in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    100 current ASM69140v1 (GCF_000691405.1) Unplaced Scaffold NW_009758133.1 (10950..51008, complement)

    NW_009758133.1Genomic Context describing neighboring genes Neighboring gene cell surface glycoprotein MUC18-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_009758133.1 Unplaced Scaffold Reference ASM69140v1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase CBL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Haliaeetus albicilla Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM69140v1

    Genomic

    1. NW_009758133.1 Reference ASM69140v1

      Range
      10950..51008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009912971.1 → XP_009911273.1  E3 ubiquitin-protein ligase CBL

      See identical proteins and their annotated locations for XP_009911273.1

      UniProtKB/TrEMBL
      A0A091P063
      Conserved Domains (5) summary
      cd09920
      Location:151 → 247
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:276 → 318
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14393
      Location:765 → 804
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      pfam02262
      Location:1 → 70
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:74 → 157
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    2. XM_009912972.1 → XP_009911274.1  E3 ubiquitin-protein ligase CBL

      See identical proteins and their annotated locations for XP_009911274.1

      UniProtKB/TrEMBL
      A0A091P063
      Conserved Domains (5) summary
      cd09920
      Location:151 → 247
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:276 → 318
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14393
      Location:765 → 804
      UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
      pfam02262
      Location:1 → 70
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:74 → 157
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    Nucleotide Protein
    Heading Accession and Version

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