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    TPH2 tryptophan hydroxylase 2 [ Ursus maritimus (polar bear) ]

    Gene ID: 103656892, updated on 11-Mar-2024

    Summary

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    Gene symbol
    TPH2
    Gene description
    tryptophan hydroxylase 2
    See related
    Ensembl:ENSUMAG00000021170
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ursus maritimus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus
    Orthologs
    human mouse all
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    Genomic context

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    See TPH2 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    101 current ASM1731132v1 (GCF_017311325.1) Unplaced Scaffold NW_024424564.1 (13270495..13377761)
    100 previous assembly UrsMar_1.0 (GCF_000687225.1) Unplaced Scaffold NW_007907046.1 (13141362..13248317)

    NW_024424564.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene TBC1 domain family member 15 Neighboring gene uncharacterized LOC103656891 Neighboring gene thyrotropin releasing hormone degrading enzyme

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tryptophan 5-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in serotonin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tryptophan 5-hydroxylase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Ursus maritimus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM1731132v1 Primary Assembly

    Genomic

    1. NW_024424564.1 Reference ASM1731132v1 Primary Assembly

      Range
      13270495..13377761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008684308.2 → XP_008682530.2  tryptophan 5-hydroxylase 2

      UniProtKB/TrEMBL
      A0A384BK82, A0A452V6M4
      Conserved Domains (1) summary
      TIGR01270
      Location:127 → 551
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    Nucleotide Protein
    Heading Accession and Version

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