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    Ric8a RIC8 guanine nucleotide exchange factor A [ Mus musculus (house mouse) ]

    Gene ID: 101489, updated on 2-Nov-2024

    Summary

    Official Symbol
    Ric8aprovided by MGI
    Official Full Name
    RIC8 guanine nucleotide exchange factor Aprovided by MGI
    Primary source
    MGI:MGI:2141866
    See related
    Ensembl:ENSMUSG00000025485 AllianceGenome:MGI:2141866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ric8; RIC-8
    Summary
    Enables G-protein alpha-subunit binding activity and protein folding chaperone. Involved in G protein-coupled receptor signaling pathway. Acts upstream of or within several processes, including basement membrane organization; gastrulation; and visual learning. Located in membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; female reproductive system; nervous system; and sensory organ. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 26.2), thymus adult (RPKM 23.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ric8a in Genome Data Viewer
    Location:
    7 F4; 7 86.06 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140437310..140443644)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140857397..140863731)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ciliary microtubule associated protein 1A Neighboring gene STARR-positive B cell enhancer ABC_E1748 Neighboring gene Bet1 golgi vesicular membrane trafficking protein like Neighboring gene sirtuin 3 Neighboring gene STARR-positive B cell enhancer ABC_E9304 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene cytochrome c oxidase subunit 8B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    synembryn-A
    Names
    resistance to inhibitors of cholinesterase 8 homolog
    synembryn

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053194.4NP_444424.1  synembryn-A

      See identical proteins and their annotated locations for NP_444424.1

      Status: VALIDATED

      Source sequence(s)
      AC107815
      Consensus CDS
      CCDS21988.1
      UniProtKB/Swiss-Prot
      Q3TEY3, Q3TIR3, Q99JW0, Q9ERR6
      Related
      ENSMUSP00000026558.7, ENSMUST00000026558.7
      Conserved Domains (1) summary
      pfam10165
      Location:67497
      Ric8; Guanine nucleotide exchange factor synembryn

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140437310..140443644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)