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    PTEN phosphatase and tensin homolog [ Orcinus orca (killer whale) ]

    Gene ID: 101289838, updated on 8-Mar-2024

    Summary

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    Gene symbol
    PTEN
    Gene description
    phosphatase and tensin homolog
    See related
    EnsemblRapid:ENSOORG00010010496
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Orcinus orca
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Delphinidae; Orcinus
    Orthologs
    human mouse all
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    Genomic context

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    See PTEN in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_02 current mOrcOrc1.1 (GCF_937001465.1) 14 NC_064572.1 (52794773..52881058)

    Chromosome 14 - NC_064572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC117196426 Neighboring gene killin, p53 regulated DNA replication inhibitor Neighboring gene uncharacterized LOC117196445 Neighboring gene gastric triacylglycerol lipase Neighboring gene uncharacterized LOC117196429

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_064572.1 Chromosome 14 Reference mOrcOrc1.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism. Liang H, et al. Cell Metab, 2014 May 6. PMID 24768297, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell motility IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
    Names
    mitochondrial PTENalpha
    NP_001296406.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309477.1 → NP_001296406.1  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

      See identical proteins and their annotated locations for NP_001296406.1

      Status: PROVISIONAL

      Source sequence(s)
      BK008845
      UniProtKB/TrEMBL
      A0A024QYS4
      Related
      ENSOORP00010013124.1, ENSOORT00010015413.1
      Conserved Domains (2) summary
      smart00404
      Location:262 → 353
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      pfam10409
      Location:358 → 519
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: GCF_937001465.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mOrcOrc1.1 Primary Assembly

    Genomic

    1. NC_064572.1 Reference mOrcOrc1.1 Primary Assembly

      Range
      52794773..52881058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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