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    PCSK9 proprotein convertase subtilisin/kexin type 9 [ Saimiri boliviensis (Bolivian squirrel monkey) ]

    Gene ID: 101049523, updated on 8-Mar-2024

    Summary

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    Gene symbol
    PCSK9
    Gene description
    proprotein convertase subtilisin/kexin type 9
    See related
    EnsemblRapid:ENSSBOG00000029957
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Saimiri boliviensis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae; Saimiriinae; Saimiri
    Also known as
    PC9
    Orthologs
    human mouse all
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    Genomic context

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    See PCSK9 in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    102 current BCM_Sbol_2.0 (GCF_016699345.1) Unplaced Scaffold NW_024100927.1 (34264818..34289716, complement)

    NW_024100927.1Genomic Context describing neighboring genes Neighboring gene glycogenin-1-like Neighboring gene ubiquitin specific peptidase 24 Neighboring gene uncharacterized LOC120365977 Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene transmembrane protein 61

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_024100927 Unplaced Scaffold Reference BCM_Sbol_2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species. Ding K, et al. PLoS One, 2007 Oct 31. PMID 17971861, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proprotein convertase subtilisin/kexin type 9
    Names
    Proprotein convertase 9
    Subtilisin/kexin-like protease PC9
    convertase subtilisin/kexin type 9 preproprotein
    NP_001266928.1
    XP_010345134.1
    XP_010345140.1
    XP_039329401.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001279999.1 → NP_001266928.1  proprotein convertase subtilisin/kexin type 9 precursor

      See identical proteins and their annotated locations for NP_001266928.1

      Status: PROVISIONAL

      Source sequence(s)
      EF692507
      UniProtKB/Swiss-Prot
      A8T695
      Related
      ENSSBOP00000027099.1, ENSSBOT00000043975.2
      Conserved Domains (3) summary
      cd04077
      Location:155 → 420
      Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
      pfam00082
      Location:179 → 421
      Peptidase_S8; Subtilase family
      pfam05922
      Location:76 → 148
      Inhibitor_I9; Peptidase inhibitor I9

    RefSeqs of Annotated Genomes: Saimiri boliviensis Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference BCM_Sbol_2.0 Primary Assembly

    Genomic

    1. NW_024100927.1 Reference BCM_Sbol_2.0 Primary Assembly

      Range
      34264818..34289716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_010346832.2 → XP_010345134.1  proprotein convertase subtilisin/kexin type 9 isoform X1

      Related
      ENSSBOP00000047871.1, ENSSBOT00000069650.1
      Conserved Domains (3) summary
      cd04077
      Location:210 → 472
      Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
      pfam00082
      Location:231 → 473
      Peptidase_S8; Subtilase family
      pfam05922
      Location:76 → 148
      Inhibitor_I9; Peptidase inhibitor I9

    2. XM_039473467.1 → XP_039329401.1  proprotein convertase subtilisin/kexin type 9 isoform X3

      Conserved Domains (2) summary
      cd04077
      Location:43 → 305
      Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
      cd16839
      Location:336 → 567
      PCSK9_C-CRD; proprotein convertase subtilisin/kexin type 9, C-terminal cysteine-rich domain (CRD)

    3. XM_010346838.2 → XP_010345140.1  proprotein convertase subtilisin/kexin type 9 isoform X2

      Conserved Domains (3) summary
      cd04077
      Location:210 → 472
      Peptidases_S8_PCSK9_ProteinaseK_like; Peptidase S8 family domain in ProteinaseK-like proteins
      pfam00082
      Location:231 → 473
      Peptidase_S8; Subtilase family
      pfam05922
      Location:76 → 148
      Inhibitor_I9; Peptidase inhibitor I9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8T695.1 GenPept UniProtKB/Swiss-Prot:A8T695

    Gene LinkOut

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