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    NPY4R2 neuropeptide Y receptor Y4-2 [ Homo sapiens (human) ]

    Gene ID: 100996758, updated on 6-Jun-2024

    Summary

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    Official Symbol
    NPY4R2provided by HGNC
    Official Full Name
    neuropeptide Y receptor Y4-2provided by HGNC
    Primary source
    HGNC:HGNC:52383
    See related
    Ensembl:ENSG00000264717 AllianceGenome:HGNC:52383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP1; NPY4R; PPYR1; NPY4-R; CH17-360D5.1
    Summary
    Enables pancreatic polypeptide receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon (RPKM 2.8), skin (RPKM 1.5) and 7 other tissues See more
    Orthologs
    all
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    Genomic context

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    See NPY4R2 in Genome Data Viewer
    Location:
    10q11.22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (47914243..47923524)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (48761016..48772396)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 (PATCHES) NW_003871068.1 (2106924..2113420)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene annexin A8 Neighboring gene shieldin complex subunit 2 pseudogene 3 Neighboring gene uncharacterized LOC124902422 Neighboring gene uncharacterized LOC102724593 Neighboring gene Sharpr-MPRA regulatory regions 2784 and 8617 duplicate 2 Neighboring gene synaptotagmin 15B Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:47089387-47089886 Neighboring gene uncharacterized LOC124902423 Neighboring gene Sharpr-MPRA regulatory region 8752 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47136815-47137314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:47769223-47769865 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:49196054-49197004 Neighboring gene NANOG hESC enhancer GRCh37_chr10:49202415-49202942 Neighboring gene family with sequence similarity 25 member C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Yan H, et al. Proc Natl Acad Sci U S A, 1996 May 14. PMID 8643460, Free PMC Article
    2. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. Bard JA, et al. J Biol Chem, 1995 Nov 10. PMID 7592911
    3. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. Lundell I, et al. J Biol Chem, 1995 Dec 8. PMID 7493937
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pancreatic polypeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neuropeptide Y receptor type 4-2
    Names
    Neuropeptide Y receptor type 4
    Neuropeptide Y receptor type 4-2
    Pancreatic polypeptide receptor 1
    neuropeptide Y receptor Y42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278795.2 → NP_001265724.1  neuropeptide Y receptor type 4-2

      See identical proteins and their annotated locations for NP_001265724.1

      Status: VALIDATED

      Source sequence(s)
      AC245041
      Consensus CDS
      CCDS81459.1
      UniProtKB/Swiss-Prot
      P0DQD5
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      cd15397
      Location:42 → 333
      7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001395253.1 → NP_001382182.1  neuropeptide Y receptor type 4-2

      Status: VALIDATED

      Source sequence(s)
      AC245041
      Consensus CDS
      CCDS81459.1
      UniProtKB/Swiss-Prot
      P0DQD5
      UniProtKB/TrEMBL
      Q4KKW2
      Related
      ENSP00000490174.1, ENST00000576178.7
      Conserved Domains (1) summary
      cd15397
      Location:42 → 333
      7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      47914243..47923524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015464.2 → XP_016870953.1  neuropeptide Y receptor type 4-2 isoform X1

      UniProtKB/Swiss-Prot
      P0DQD5
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      cd15397
      Location:42 → 333
      7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_011539115.3 → XP_011537417.1  neuropeptide Y receptor type 4-2 isoform X1

      See identical proteins and their annotated locations for XP_011537417.1

      UniProtKB/Swiss-Prot
      P0DQD5
      UniProtKB/TrEMBL
      Q4KKW2
      Conserved Domains (1) summary
      cd15397
      Location:42 → 333
      7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_006717545.4 → XP_006717608.1  neuropeptide Y receptor type 4-2 isoform X1

      See identical proteins and their annotated locations for XP_006717608.1

      UniProtKB/Swiss-Prot
      P0DQD5
      UniProtKB/TrEMBL
      Q4KKW2
      Related
      ENSP00000489924.1, ENST00000613306.1
      Conserved Domains (1) summary
      cd15397
      Location:42 → 333
      7tmA_NPY4R; neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160001.1 Reference GRCh38.p14 PATCHES

      Range
      130393..141806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332437.1 → XP_054188412.1  neuropeptide Y receptor type 4-2 isoform X1

      UniProtKB/Swiss-Prot
      P0DQD5
      UniProtKB/TrEMBL
      Q4KKW2

    2. XM_054332438.1 → XP_054188413.1  neuropeptide Y receptor type 4-2 isoform X1

      UniProtKB/Swiss-Prot
      P0DQD5
      UniProtKB/TrEMBL
      Q4KKW2

    3. XM_054332436.1 → XP_054188411.1  neuropeptide Y receptor type 4-2 isoform X1

      UniProtKB/Swiss-Prot
      P0DQD5
      UniProtKB/TrEMBL
      Q4KKW2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      48761016..48772396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364464.1 → XP_054220439.1  neuropeptide Y receptor type 4-2 isoform X1

      UniProtKB/TrEMBL
      Q4KKW2

    2. XM_054364467.1 → XP_054220442.1  neuropeptide Y receptor type 4-2 isoform X1

      UniProtKB/TrEMBL
      Q4KKW2

    3. XM_054364465.1 → XP_054220440.1  neuropeptide Y receptor type 4-2 isoform X1

      UniProtKB/TrEMBL
      Q4KKW2

    4. XM_054364466.1 → XP_054220441.1  neuropeptide Y receptor type 4-2 isoform X1

      UniProtKB/TrEMBL
      Q4KKW2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DQD5.1 GenPept UniProtKB/Swiss-Prot:P0DQD5

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