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    Eps8 EGFR pathway substrate 8, signaling adaptor [ Cricetulus griseus (Chinese hamster) ]

    Gene ID: 100750968, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Eps8
    Gene description
    EGFR pathway substrate 8, signaling adaptor
    See related
    Ensembl:ENSCGRG00015001138
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cricetulus griseus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
    Orthologs
    human mouse all
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    Genomic context

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    See Eps8 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003613820.1 (1633923..1793356)
    104 current CriGri-PICRH-1.0 (GCF_003668045.3) 8 NC_048601.1 (11382479..11545010)

    NW_003613820.1Genomic Context describing neighboring genes Neighboring gene SNRPN upstream reading frame protein-like Neighboring gene small nuclear ribonucleoprotein-associated protein N-like Neighboring gene protein tyrosine phosphatase receptor type O

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    epidermal growth factor receptor kinase substrate 8
    Names
    Epidermal growth factor receptor kinase substrate 8
    epidermal growth factor receptor pathway substrate 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CriGri_1.0 Primary Assembly

    Genomic

    1. NW_003613820.1 Reference CriGri_1.0 Primary Assembly

      Range
      1633923..1793356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007641642.4 → XP_007639832.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      See identical proteins and their annotated locations for XP_007639832.1

      UniProtKB/TrEMBL
      A0A061I028, G3H9Z5
      Conserved Domains (3) summary
      cd09540
      Location:719 → 783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534 → 587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    2. XM_003500911.5 → XP_003500959.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      See identical proteins and their annotated locations for XP_003500959.1

      UniProtKB/TrEMBL
      A0A061I028, G3H9Z5
      Conserved Domains (3) summary
      cd09540
      Location:719 → 783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534 → 587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    3. XM_027435549.2 → XP_027291350.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A061I028, G3H9Z5
      Conserved Domains (3) summary
      cd09540
      Location:719 → 783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534 → 587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    4. XM_027435548.2 → XP_027291349.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A061I028, A0A9J7K0U4

    5. XM_007641643.4 → XP_007639833.1  epidermal growth factor receptor kinase substrate 8 isoform X3

      UniProtKB/TrEMBL
      A0A9J7GHD5
      Conserved Domains (2) summary
      cd09540
      Location:459 → 523
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:274 → 327
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins

    Alternate CriGri-PICRH-1.0

    Genomic

    1. NC_048601.1 Alternate CriGri-PICRH-1.0

      Range
      11382479..11545010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027429928.2 → XP_027285729.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A061I028, G3H9Z5
      Conserved Domains (3) summary
      cd09540
      Location:719 → 783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534 → 587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    2. XM_035448876.1 → XP_035304767.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A061I028, G3H9Z5
      Conserved Domains (3) summary
      cd09540
      Location:719 → 783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534 → 587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    3. XM_027429925.2 → XP_027285726.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A061I028, G3H9Z5
      Conserved Domains (3) summary
      cd09540
      Location:719 → 783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534 → 587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    4. XM_027429923.2 → XP_027285724.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A061I028, G3H9Z5
      Conserved Domains (3) summary
      cd09540
      Location:719 → 783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534 → 587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    5. XM_027429926.2 → XP_027285727.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A061I028, G3H9Z5
      Conserved Domains (3) summary
      cd09540
      Location:719 → 783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534 → 587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    6. XM_035448877.1 → XP_035304768.1  epidermal growth factor receptor kinase substrate 8 isoform X2

      UniProtKB/TrEMBL
      A0A061I028, G3H9Z5
      Related
      ENSCGRP00015001528.1, ENSCGRT00015001925.2
      Conserved Domains (3) summary
      cd09540
      Location:719 → 783
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:534 → 587
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cd01210
      Location:64 → 191
      PTB_EPS8; Epidermal growth factor receptor kinase substrate (EPS8)-like Phosphotyrosine-binding (PTB) domain

    7. XM_027429922.2 → XP_027285723.1  epidermal growth factor receptor kinase substrate 8 isoform X1

      UniProtKB/TrEMBL
      A0A061I028, A0A9J7K0U4
      Related
      ENSCGRP00015001300.2, ENSCGRT00015001656.2

    8. XM_027429929.2 → XP_027285730.1  epidermal growth factor receptor kinase substrate 8 isoform X3

      UniProtKB/TrEMBL
      A0A9J7GHD5
    Nucleotide Protein Strain
    Heading Accession and Version

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