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    ERVK-10 endogenous retrovirus group K member 10 [ Homo sapiens (human) ]

    Gene ID: 100616101, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ERVK-10provided by HGNC
    Official Full Name
    endogenous retrovirus group K member 10provided by HGNC
    Primary source
    HGNC:HGNC:39004
    Gene type
    other
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR; Protease; Proteinase
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    Genomic context

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    Location:
    5q33.3

    Bibliography

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    Related articles in PubMed

    1. Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells. Zhou F, et al. Oncotarget, 2016 Dec 20. PMID 27557521, Free PMC Article
    2. Inhibition of human endogenous retrovirus-K10 protease in cell-free and cell-based assays. Kuhelj R, et al. J Biol Chem, 2001 May 18. PMID 11278433
    3. Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease? Towler EM, et al. Biochemistry, 1998 Dec 8. PMID 9860826
    4. Characterization of human endogenous retrovirus type K virus-like particles generated from recombinant baculoviruses. Tönjes RR, et al. Virology, 1997 Jul 7. PMID 9217052
    5. Characterization of the human endogenous retrovirus K proteinase. Schommer S, et al. J Gen Virol, 1996 Feb. PMID 8627242

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that human endogenous retrovirus type K (HERV-K10) Env protein plays an important role in tumorigenesis and metastasis of breast cancer (BC).
      Title: Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells.
    2. Np9 contributes to the regulation of the p53-MDM2 pathway specifically in humans, chimpanzees and gorillas.
      Title: Np9, a cellular protein of retroviral ancestry restricted to human, chimpanzee and gorilla, binds and regulates ubiquitin ligase MDM2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • Endogenous retrovirus group K member 10 Np9 protein
    • Gag polyprotein
    • Gag-Pro-Pol protein
    • HERV-K10 Np9 protein
    • HERV-K107 Np9 protein
    • HERV-K_5q33.3 provirus Np9 protein
    • HERV-K_5q33.3 provirus ancestral Gag polyprotein
    • HERV-K_5q33.3 provirus ancestral Pol protein
    • HERV-K_5q33.3 provirus ancestral Pro protein

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA stem-loop binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10265.2 GenPept UniProtKB/Swiss-Prot:P10265
    P10266.2 GenPept UniProtKB/Swiss-Prot:P10266
    P61580.1 GenPept UniProtKB/Swiss-Prot:P61580
    P87889.4 GenPept UniProtKB/Swiss-Prot:P87889

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