EGFR-AS1 EGFR antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EGFR-AS1provided by HGNC
Official Full Name: EGFR antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:40207
See related: Ensembl:ENSG00000224057 AllianceGenome:HGNC:40207
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Broad expression in placenta (RPKM 4.4), small intestine (RPKM 1.8) and 18 other tissues See more
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Genomic context

Location:: 7p11.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (55179750..55188949, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (55340174..55349373, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (55247443..55256642, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression.
Title: TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression.
lncRNA EGFR-AS1 facilitates leiomyosarcoma progression and immune escape via the EGFR-MYC-PD-L1 axis.
Title: lncRNA EGFR-AS1 facilitates leiomyosarcoma progression and immune escape via the EGFR-MYC-PD-L1 axis.
Genetic variant rs10251977 (G>A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D.
Title: Genetic variant rs10251977 (G>A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D.
Long non-coding RNA EGFR-AS1 in colorectal cancer: potential role in tumorigenesis and survival via miRNA-133b sponge and EGFR/STAT3 axis regulation.
Title: Long non-coding RNA EGFR-AS1 in colorectal cancer: potential role in tumorigenesis and survival via miRNA-133b sponge and EGFR/STAT3 axis regulation.
EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR.
Title: EGFR-AS1 Promotes Bladder Cancer Progression by Upregulating EGFR.
LncRNA EGFR-AS1 Upregulates ROCK1 by Sponging miR-145 to Promote Esophageal Squamous Cell Carcinoma Cell Invasion and Migration.
Title: LncRNA EGFR-AS1 Upregulates ROCK1 by Sponging miR-145 to Promote Esophageal Squamous Cell Carcinoma Cell Invasion and Migration.
EGFR-AS1 was significantly upregulated in renal cell carcinoma tissues, and enhances the malignant phenotype of renal cell carcinoma cells by enhancing HuR-mediated mRNA stability of EGFR.
Title: Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer.
These findings elucidated that EGFR-AS1 accelerated cell proliferation, migration, invasion and prevented apoptosis in glioma cells by regulating miR-133b/RACK1, providing new insights for the diagnosis and molecular therapy of Glioblastoma multiforme.
Title: The lncRNA EGFR-AS1 is linked to migration, invasion and apoptosis in glioma cells by targeting miR-133b/RACK1.
The expression of lncRNA EGFR-AS1 is decreased in preeclampsia patients, promoting disease progression by inhibiting EGFR-JAK/STAT signaling pathway.
Title: Lowly expressed EGFR-AS1 promotes the progression of preeclampsia by inhibiting the EGFR-JAK/STAT signaling pathway.
Data found that EGFRAS1 was abnormally upregulated in nonsmall cell lung cancer (NSCLC) tissues and in plasma samples from patients with cisplatin-based chemotherapy resistance. Further results confirmed that EGFRAS1 mediated cell proliferation and chemoresistance through directly binding to microRNA223. Therefore, EGFRAS1 overexpression-induced chemoresistance can contribute to poor prognosis in NSCLC.
Title: Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Markers

RH94246 (e-PCR)
- UniSTS:85508

SHGC-57944 (e-PCR)
- UniSTS:18550

SHGC-58597 (e-PCR)
- UniSTS:94416

SHGC-32574 (e-PCR)
- UniSTS:79840

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.