Ccl21e C-C motif chemokine ligand 21E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccl21eprovided by MGI
Official Full Name: C-C motif chemokine ligand 21Eprovided by MGI
Primary source: MGI:MGI:3711256
See related: Ensembl:ENSMUSG00000096596 AllianceGenome:MGI:3711256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TCA4; 6Ckine; Ccl21b; Ccl21c; Scya21; Gm10591; Scya21b; Scya21c
Expression: Broad expression in thymus adult (RPKM 79.5), spleen adult (RPKM 54.9) and 15 other tissues See more
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Genomic context

Location:: 4 A5; 4 22.7 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (42612123..42613253)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (42612123..42613253)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AI159701 (e-PCR)
- UniSTS:159233

Ccl21a (e-PCR), detects polymorphism
- UniSTS:530815

AW987545 (e-PCR)
- UniSTS:185579

Ccl21a (e-PCR), detects polymorphism
- UniSTS:526069

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
involved_in mesangial cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendritic cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myeloid dendritic cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pseudopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to prostaglandin E	ISO Inferred from Sequence Orthology more info
involved_in ruffle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: C-C motif chemokine 21b

Names: Beta-chemokine exodus-2; C-C motif chemokine 21c; Small-inducible cytokine A21b; Small-inducible cytokine A21c; Thymus-derived chemotactic agent 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193668.1 → NP_001180597.1 C-C motif chemokine 21b precursor

See identical proteins and their annotated locations for NP_001180597.1

Status: VALIDATED

Source sequence(s)

BX666061

Consensus CDS

CCDS51158.1

UniProtKB/Swiss-Prot

P84443, P86792, P86793, Q5M8M5

Related

ENSMUSP00000136903.2, ENSMUST00000178168.3

Conserved Domains (1) summary

cl00134
Location:29 → 91

Chemokine; small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 ...