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    chrne cholinergic receptor, nicotinic epsilon [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100497712, updated on 4-Nov-2024

    Summary

    Official Symbol
    chrneprovided by Xenbase
    Official Full Name
    cholinergic receptor, nicotinic epsilonprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-979686
    See related
    Ensembl:ENSXETG00000014957 AllianceGenome:Xenbase:XB-GENE-979686
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity and transmembrane signaling receptor activity. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome; congenital myasthenic syndrome 4A; congenital myasthenic syndrome 4B; and congenital myasthenic syndrome 4C. Orthologous to human CHRNE (cholinergic receptor nicotinic epsilon subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See chrne in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (147415838..147433627, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) Unplaced Scaffold NW_016683461.1 (84384..110736, complement)

    Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101730300 Neighboring gene estradiol 17-beta-dehydrogenase 12-B-like Neighboring gene Uncharacterized LOC548830 Neighboring gene platelet glycoprotein Ib alpha chain Neighboring gene solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    acetylcholine receptor subunit epsilon
    Names
    cholinergic receptor, nicotinic, epsilon (muscle)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      147415838..147433627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002941821.5XP_002941867.4  acetylcholine receptor subunit epsilon

      UniProtKB/TrEMBL
      A0A6I8RKL1, A0A8J0QTF3
      Related
      ENSXETP00000032716.5, ENSXETT00000032716.5
      Conserved Domains (2) summary
      cd19029
      Location:47241
      LGIC_ECD_nAChR_G; extracellular domain of nicotinic acetylcholine receptor subunit gamma (CHRNG)
      pfam02932
      Location:248491
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region