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    DKK1 dickkopf WNT signaling pathway inhibitor 1 [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100435550, updated on 26-Mar-2024

    Summary

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    Gene symbol
    DKK1
    Gene description
    dickkopf WNT signaling pathway inhibitor 1
    Locus tag
    CR201_G0008318
    See related
    Ensembl:ENSPPYG00000002438
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs
    human mouse all
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    Genomic context

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    See DKK1 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 8 NC_071993.2 (92104166..92107568, complement)
    RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 10 NC_071995.1 (88259285..88270235, complement)

    Chromosome 8 - NC_071993.2Genomic Context describing neighboring genes Neighboring gene 52 kDa repressor of the inhibitor of the protein kinase-like Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene protein kinase cGMP-dependent 1 Neighboring gene cleavage stimulation factor subunit 2 tau variant Neighboring gene low molecular weight phosphotyrosine protein phosphatase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables co-receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dickkopf-related protein 1-like; uncharacterized protein LOC100435550
    Names
    dickkopf-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260480.1 → NP_001247409.1  dickkopf-related protein 1-like precursor

      See identical proteins and their annotated locations for NP_001247409.1

      Status: PROVISIONAL

      Source sequence(s)
      JN966750
      UniProtKB/TrEMBL
      A0A2J8WQU7, A0A6D2WDD7, H2NAV8
      Related
      ENSPPYP00000002828.2, ENSPPYT00000002928.3
      Conserved Domains (2) summary
      pfam04706
      Location:85 → 139
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
      pfam04706
      Location:85 → 139
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    2. NM_001260480.1 → NP_001247409.1  uncharacterized protein LOC100435550 precursor

      See identical proteins and their annotated locations for NP_001247409.1

      Status: PROVISIONAL

      Source sequence(s)
      JN966750
      UniProtKB/TrEMBL
      A0A2J8WQU7, A0A6D2WDD7, H2NAV8
      Related
      ENSPPYP00000002828.2, ENSPPYT00000002928.3
      Conserved Domains (2) summary
      pfam04706
      Location:85 → 139
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
      pfam04706
      Location:85 → 139
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Genomic

    1. NC_071993.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

      Range
      92104166..92107568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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