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    frs3 fibroblast growth factor receptor substrate 3 [ Danio rerio (zebrafish) ]

    Gene ID: 100330147, updated on 2-Nov-2024

    Summary

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    Official Symbol
    frs3provided by ZNC
    Official Full Name
    fibroblast growth factor receptor substrate 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-131121-119
    See related
    Ensembl:ENSDARG00000078688 AllianceGenome:ZFIN:ZDB-GENE-131121-119
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-177p8.1
    Summary
    Predicted to enable fibroblast growth factor receptor binding activity and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in female organism. Orthologous to human FRS3 (fibroblast growth factor receptor substrate 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See frs3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (40587683..40610479)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (40590056..40608831)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 6 homolog (yeast) Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 Neighboring gene translocator protein Neighboring gene solute carrier family 6 member 11a Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 1 Neighboring gene microRNA 429b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor receptor substrate 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      40587683..40610479
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002662499.7 → XP_002662545.2  fibroblast growth factor receptor substrate 2

      UniProtKB/TrEMBL
      A0A8M1RDK1, E7F020
      Related
      ENSDARP00000129472.1, ENSDART00000155554.2
      Conserved Domains (1) summary
      cd01202
      Location:15 → 106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

    2. XM_021477232.2 → XP_021332907.1  fibroblast growth factor receptor substrate 2

      UniProtKB/TrEMBL
      A0A8M1RDK1, E7F020
      Conserved Domains (1) summary
      cd01202
      Location:15 → 106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain
    Nucleotide Protein
    Heading Accession and Version

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