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    nsun6 NOP2/Sun RNA methyltransferase 6 [ Danio rerio (zebrafish) ]

    Gene ID: 100149557, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nsun6provided by ZNC
    Official Full Name
    NOP2/Sun RNA methyltransferase 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080808-8
    See related
    Ensembl:ENSDARG00000103478 AllianceGenome:ZFIN:ZDB-GENE-080808-8
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable RNA binding activity and RNA methyltransferase activity. Predicted to be involved in RNA methylation. Predicted to act upstream of or within methylation. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 82. Orthologous to human NSUN6 (NOP2/Sun RNA methyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nsun6 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71777001..71813102)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71585139..71621117)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene myomesin 1b Neighboring gene myosin, light chain 12, genome duplicate 1 Neighboring gene calcium channel, voltage-dependent, beta 2a Neighboring gene low density lipoprotein receptor-related protein 4 Neighboring gene low-density lipoprotein receptor-related protein 4-like Neighboring gene proteasome 26S subunit, non-ATPase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    2. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (cytosine(72)-C(5))-methyltransferase NSUN6
    Names
    NOL1/NOP2/Sun domain family, member 6
    NOP2/Sun domain family, member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      71777001..71813102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357149.3 → XP_017212638.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IAT4, A0A8M2BGC6
      Related
      ENSDARP00000153997.1, ENSDART00000189745.1
      Conserved Domains (3) summary
      smart00359
      Location:112 → 200
      PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
      COG0144
      Location:185 → 459
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:226 → 456
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_005169055.5 → XP_005169112.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X1

      See identical proteins and their annotated locations for XP_005169112.1

      UniProtKB/TrEMBL
      A0A0R4IAT4, A0A8M2BGC6
      Related
      ENSDARP00000131024.1, ENSDART00000158782.2
      Conserved Domains (3) summary
      smart00359
      Location:112 → 200
      PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
      COG0144
      Location:185 → 459
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:226 → 456
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_017357152.3 → XP_017212641.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z0B3
      Conserved Domains (3) summary
      smart00359
      Location:111 → 199
      PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
      COG0144
      Location:184 → 458
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:225 → 455
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_017357151.3 → XP_017212640.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IAT4, A0A8M2BGC6
      Conserved Domains (3) summary
      smart00359
      Location:112 → 200
      PUA; Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase
      COG0144
      Location:185 → 459
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
      cl17173
      Location:226 → 456
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_068222795.1 → XP_068078896.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X1

      Related
      ENSDARP00000137583.1, ENSDART00000161344.3

    6. XM_068222797.1 → XP_068078898.1  tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 isoform X2

    Nucleotide Protein
    Heading Accession and Version

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