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    LIPA lipase A, lysosomal acid type [ Bos taurus (domestic cattle) ]

    Gene ID: 100125267, updated on 4-Oct-2024

    Summary

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    Official Symbol
    LIPAprovided by VGNC
    Official Full Name
    lipase A, lysosomal acid typeprovided by VGNC
    Primary source
    VGNC:VGNC:30904
    See related
    BGD:BT15114; Ensembl:ENSBTAG00000003636
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See LIPA in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 26 NC_037353.1 (10952398..11081825, complement)

    Chromosome 26 - NC_037353.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104975941 Neighboring gene cholesterol 25-hydroxylase Neighboring gene uncharacterized LOC112444523 Neighboring gene DNA fragmentation factor subunit alpha-like Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene eukaryotic translation initiation factor 4E-like Neighboring gene interferon induced protein with tetratricopeptide repeats 2 Neighboring gene interferon induced protein with tetratricopeptide repeats 3 Neighboring gene solute carrier family 16 member 12 Neighboring gene interferon induced protein with tetratricopeptide repeats 5 Neighboring gene uncharacterized LOC100847358 Neighboring gene pantothenate kinase 1 Neighboring gene microRNA mir-107

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC159953

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables sterol ester esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lysosomal acid lipase/cholesteryl ester hydrolase
    Names
    lipase A, lysosomal acid, cholesterol esterase
    NP_001096793.1
    XP_059737694.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103323.1 → NP_001096793.1  lysosomal acid lipase/cholesteryl ester hydrolase precursor

      See identical proteins and their annotated locations for NP_001096793.1

      Status: PROVISIONAL

      Source sequence(s)
      BC146075
      UniProtKB/TrEMBL
      A6H713, F1N110
      Related
      ENSBTAP00000014997.6, ENSBTAT00000014997.6
      Conserved Domains (3) summary
      pfam00561
      Location:80 → 380
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:37 → 99
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:80 → 246
      Abhydrolase_5; Alpha/beta hydrolase family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037353.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      10952398..11081825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059881711.1 → XP_059737694.1  lysosomal acid lipase/cholesteryl ester hydrolase isoform X1

      UniProtKB/TrEMBL
      A6H713, F1N110
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials