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    HECTD1 HECT domain E3 ubiquitin protein ligase 1 [ Equus caballus (horse) ]

    Gene ID: 100050203, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HECTD1provided by VGNC
    Official Full Name
    HECT domain E3 ubiquitin protein ligase 1provided by VGNC
    Primary source
    VGNC:VGNC:18735
    See related
    Ensembl:ENSECAG00000023505
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See HECTD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 1 NC_009144.3 (170535555..170623391, complement)

    Chromosome 1 - NC_009144.3Genomic Context describing neighboring genes Neighboring gene striatin 3 Neighboring gene uncharacterized LOC111769672 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene 40S ribosomal protein S10 pseudogene Neighboring gene HEAT repeat containing 5A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009144.3 Chromosome 1 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HECTD1
    Names
    HECT domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009144.3 Reference EquCab3.0 Primary Assembly

      Range
      170535555..170623391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005603422.3 → XP_005603479.2  E3 ubiquitin-protein ligase HECTD1 isoform X5

      UniProtKB/TrEMBL
      F6YMU8
      Related
      ENSECAP00000021258.3, ENSECAT00000025553.3
      Conserved Domains (5) summary
      cd00078
      Location:1852 → 2329
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369 → 479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1302
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal

    2. XM_005603419.3 → XP_005603476.2  E3 ubiquitin-protein ligase HECTD1 isoform X3

      UniProtKB/TrEMBL
      F6YMU8
      Related
      ENSECAP00000063582.1, ENSECAT00000122516.1
      Conserved Domains (5) summary
      cd00078
      Location:2084 → 2561
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369 → 479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1321
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal

    3. XM_014734146.2 → XP_014589632.2  E3 ubiquitin-protein ligase HECTD1 isoform X2

      UniProtKB/TrEMBL
      F6YMU8
      Conserved Domains (5) summary
      cd00078
      Location:2129 → 2606
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369 → 479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal

    4. XM_014734147.2 → XP_014589633.2  E3 ubiquitin-protein ligase HECTD1 isoform X4

      UniProtKB/TrEMBL
      F6YMU8, F6YN41
      Related
      ENSECAP00000021245.2, ENSECAT00000025538.4
      Conserved Domains (5) summary
      cd00078
      Location:2070 → 2547
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369 → 479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal

    5. XM_001489863.6 → XP_001489913.3  E3 ubiquitin-protein ligase HECTD1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q2L991, F6YMU8
      Related
      ENSECAP00000035860.1, ENSECAT00000058185.2
      Conserved Domains (5) summary
      cd00078
      Location:2131 → 2608
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:369 → 479
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:396 → 426
      ANK; ANK repeat [structural motif]
      pfam06701
      Location:1277 → 1335
      MIB_HERC2; Mib_herc2
      pfam07738
      Location:1107 → 1240
      Sad1_UNC; Sad1 / UNC-like C-terminal
    Nucleotide Protein
    Heading Accession and Version

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