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    Hsd3b9 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9 [ Mus musculus (house mouse) ]

    Gene ID: 100043461, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hsd3b9provided by MGI
    Official Full Name
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9provided by MGI
    Primary source
    MGI:MGI:3782634
    See related
    Ensembl:ENSMUSG00000090817 AllianceGenome:MGI:3782634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4450
    Summary
    Predicted to enable 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity; steroid binding activity; and steroid delta-isomerase activity. Predicted to be involved in progesterone metabolic process; regulation of steroid biosynthetic process; and steroid biosynthetic process. Predicted to be located in several cellular components, including intercellular bridge; mitochondrial envelope; and nucleolus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; eye; heart; integumental system; and nervous system. Human ortholog(s) of this gene implicated in hypertension and hypospadias. Orthologous to human HSD3B1 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1) and HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 427.6) See more
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    Genomic context

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    See Hsd3b9 in Genome Data Viewer
    Location:
    3 F2.2; 3 42.77 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98352991..98364833, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98445675..98457517, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4565 Neighboring gene STARR-positive B cell enhancer ABC_E11203 Neighboring gene 3-phosphoglycerate dehydrogenase Neighboring gene STARR-positive B cell enhancer ABC_E7932 Neighboring gene predicted gene, 31420 Neighboring gene zinc finger protein 697 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:98210571-98210772 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 pseudogene Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of several members of the murine Hsd3b gene family. Clarke TR, et al. DNA Cell Biol, 1996 May. PMID 8924213
    2. The genes encoding gonadal and nongonadal forms of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are closely linked on mouse chromosome 3. Bain PA, et al. Genomics, 1993 Apr. PMID 8486361
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid delta-isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in C21-steroid hormone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in progesterone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NADPH-dependent 3-keto-steroid reductase Hsd3b4
    Names
    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase-like
    NP_001357799.1
    XP_001480548.2
    XP_011238657.1
    XP_017175350.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370870.1 → NP_001357799.1  NADPH-dependent 3-keto-steroid reductase Hsd3b4

      Status: VALIDATED

      Source sequence(s)
      AC161053
      Consensus CDS
      CCDS89670.1
      UniProtKB/TrEMBL
      E9Q007
      Related
      ENSMUSP00000127882.2, ENSMUST00000167753.8
      Conserved Domains (1) summary
      cl21454
      Location:5 → 357
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      98352991..98364833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319861.2 → XP_017175350.1  NADPH-dependent 3-keto-steroid reductase Hsd3b4 isoform X2

      UniProtKB/TrEMBL
      E9Q007
      Conserved Domains (1) summary
      cl21454
      Location:5 → 357
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_001480498.5 → XP_001480548.2  NADPH-dependent 3-keto-steroid reductase Hsd3b4 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:31 → 383
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_011240355.1 → XP_011238657.1  NADPH-dependent 3-keto-steroid reductase Hsd3b4 isoform X2

      See identical proteins and their annotated locations for XP_011238657.1

      UniProtKB/TrEMBL
      E9Q007
      Conserved Domains (1) summary
      cl21454
      Location:5 → 357
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version

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