MAPKAPK2 MAPK activated protein kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPKAPK2provided by HGNC
Official Full Name: MAPK activated protein kinase 2provided by HGNC
Primary source: HGNC:HGNC:6887
See related: Ensembl:ENSG00000162889 MIM:602006; AllianceGenome:HGNC:6887
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MK2; MK-2; MAPKAP-K2
Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 54.9), heart (RPKM 45.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (206684905..206734281)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (205949085..205998488)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (206858250..206907626)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitogen-activated protein kinase-activated protein kinase-2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer.
Title: Mitogen-activated protein kinase-activated protein kinase-2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer.
Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2.
Title: Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2.
MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate.
Title: MK2 degradation as a sensor of signal intensity that controls stress-induced cell fate.
MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Title: MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.
Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2 with distinct physiological properties.
Title: Alternative Translation Initiation Generates a Functionally Distinct Isoform of the Stress-Activated Protein Kinase MK2.
our results suggest that the MAPKAPK2 plays a key role in Sophoridine-inhibited growth and invasion in colorectal cancers.
Title: Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2.
Studies present evidence that MK2 play a central role in the regulation of the inflammatory pathways in chronic airway inflammatory diseases. [review]
Title: Novel Therapeutic Potential of Mitogen-Activated Protein Kinase Activated Protein Kinase 2 (MK2) in Chronic Airway Inflammatory Disorders.
Overexpression of microRNA-490-3p alleviates inflammation and apoptosis via targeting MK2, thereafter promoting spinal cord injury recovery.
Title: MicroRNA-490-3p inhibits inflammation and apoptosis induced by spinal cord injury via targeting MK2.
The MK2 phosphorylates a cytoplasmic pool of RIPK1 that presumably subsequently integrates complex I, while IKKalpha/beta phosphorylate RIPK1 directly in complex I.
Title: MK2 puts an additional brake on RIPK1 cytotoxic potential.
Altogether, MAPKAPK2 is responsible for regulating the transcript stability and is functionally important to modulate Head and neck squamous-cell carcinoma pathogenesis.
Title: MAPKAPK2 plays a crucial role in the progression of head and neck squamous cell carcinoma by regulating transcript stability.

Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 decreases adult neural progenitor cell proliferation via the p38 MAPK-MAPKAPK2-Cdc25C signaling pathway	PubMed
Vpr	vpr	Kinase Srk1/MK2 is required for the Vpr-mediated nuclear export of Cdc25	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-76226 (e-PCR)
- UniSTS:67385

D1S3257 (e-PCR)
- UniSTS:9025

SHGC-34637 (e-PCR)
- UniSTS:59742

RH70252 (e-PCR)
- UniSTS:34662

SHGC-145653 (e-PCR)
- UniSTS:174709

RH70191 (e-PCR)
- UniSTS:56733

AL010045 (e-PCR)
- UniSTS:28363

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to vascular endothelial growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner ear development	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukotriene metabolic process	TAS Traceable Author Statement more info
involved_in macropinocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macrophage cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cellular response to heat	TAS Traceable Author Statement more info
involved_in regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA stability	TAS Traceable Author Statement more info
involved_in regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info
involved_in response to cytokine	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cytokine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: MAP kinase-activated protein kinase 2

Names: MAPKAP kinase 2; mitogen-activated protein kinase-activated protein kinase 2

NP_004750.1

EC 2.7.11.1

NP_116584.2

EC 2.7.11.1

XP_005273410.1

EC 2.7.11.1

XP_016858299.1

EC 2.7.11.1

XP_047290374.1

EC 2.7.11.1

XP_054195605.1

EC 2.7.11.1

XP_054195606.1

EC 2.7.11.1

XP_054195607.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029640.1 RefSeqGene

Range

4886..54262

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004759.5 → NP_004750.1 MAP kinase-activated protein kinase 2 isoform 1

See identical proteins and their annotated locations for NP_004750.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).

Source sequence(s)

AL591846, BC036060, BC052584, BU621009

Consensus CDS

CCDS1466.1

UniProtKB/Swiss-Prot

P49137

Related

ENSP00000294981.4, ENST00000294981.8

Conserved Domains (2) summary

smart00220
Location:68 → 325

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14170
Location:61 → 353

STKc_MAPKAPK2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2
NM_032960.4 → NP_116584.2 MAP kinase-activated protein kinase 2 isoform 2

See identical proteins and their annotated locations for NP_116584.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL591846, BC036060, BC052584, BU621009

Consensus CDS

CCDS31001.1

UniProtKB/Swiss-Prot

P49137, Q5SY30, Q5SY41, Q8IYD6

Related

ENSP00000356070.4, ENST00000367103.4

Conserved Domains (1) summary

cd14170
Location:61 → 363

STKc_MAPKAPK2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

206684905..206734281

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005273353.4 → XP_005273410.1 MAP kinase-activated protein kinase 2 isoform X1

Conserved Domains (2) summary

smart00220
Location:68 → 325

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14170
Location:61 → 353

STKc_MAPKAPK2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2
XM_017002810.2 → XP_016858299.1 MAP kinase-activated protein kinase 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 270

PKc_like; Protein Kinases, catalytic domain
XM_047434418.1 → XP_047290374.1 MAP kinase-activated protein kinase 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

205949085..205998488

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054339630.1 → XP_054195605.1 MAP kinase-activated protein kinase 2 isoform X1
XM_054339631.1 → XP_054195606.1 MAP kinase-activated protein kinase 2 isoform X2
XM_054339632.1 → XP_054195607.1 MAP kinase-activated protein kinase 2 isoform X3