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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_029100.2 RefSeqGene
- Range
-
5014..46749
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001319224.2 → NP_001306153.1 exonuclease 1 isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is 1 aa shorter compared to isoform b.
- Source sequence(s)
-
AK291291, AL365366, CA430743, DA479425
- UniProtKB/TrEMBL
-
A8K5H6
- Conserved Domains (3) summary
-
- cd09908
Location:213 → 289
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 206
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 308
- fen_arch; flap structure-specific endonuclease
-
NM_003686.4 → NP_003677.4 exonuclease 1 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) uses an alternate splice site in the 3' end of the coding region, resulting in a frameshift and use of an upstream stop codon, as compared to variant 1. It encodes isoform a, which is 43 aa shorter than isoform b.
- Source sequence(s)
-
AL365366, BC007491, CA430743
- Consensus CDS
-
CCDS44336.1
- UniProtKB/TrEMBL
-
A8K5H6
- Related
- ENSP00000430251.1, ENST00000518483.5
- Conserved Domains (3) summary
-
- cd09908
Location:213 → 289
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 206
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 308
- fen_arch; flap structure-specific endonuclease
-
NM_006027.4 → NP_006018.4 exonuclease 1 isoform b
See identical proteins and their annotated locations for NP_006018.4
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (b). Both variants 1 and 2 encode isoform b.
- Source sequence(s)
-
AL365366, BC007491, CA430743
- Consensus CDS
-
CCDS1620.1
- UniProtKB/Swiss-Prot
- O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0, Q9UQ84
- UniProtKB/TrEMBL
-
A8K5H6
- Related
- ENSP00000311873.5, ENST00000348581.9
- Conserved Domains (3) summary
-
- cd09908
Location:213 → 289
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 206
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 308
- fen_arch; flap structure-specific endonuclease
-
NM_130398.4 → NP_569082.2 exonuclease 1 isoform b
See identical proteins and their annotated locations for NP_569082.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) includes a unique exon in its 5' UTR, as compared to variant 1. Both variants 1 and 2 encode isoform b.
- Source sequence(s)
-
AL365366, BC007491, CA430743, CN348533, DA661516
- Consensus CDS
-
CCDS1620.1
- UniProtKB/Swiss-Prot
- O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0, Q9UQ84
- UniProtKB/TrEMBL
-
A8K5H6
- Related
- ENSP00000355506.3, ENST00000366548.8
- Conserved Domains (3) summary
-
- cd09908
Location:213 → 289
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 206
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 308
- fen_arch; flap structure-specific endonuclease
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000001.11 Reference GRCh38.p14 Primary Assembly
- Range
-
241847986..241889939
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_047434104.1 → XP_047290060.1 exonuclease 1 isoform X1
- UniProtKB/Swiss-Prot
- O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0, Q9UQ84
-
XM_047434112.1 → XP_047290068.1 exonuclease 1 isoform X2
-
XM_047434106.1 → XP_047290062.1 exonuclease 1 isoform X1
- UniProtKB/Swiss-Prot
- O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0, Q9UQ84
-
XM_011544322.2 → XP_011542624.1 exonuclease 1 isoform X1
See identical proteins and their annotated locations for XP_011542624.1
- UniProtKB/Swiss-Prot
- O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0, Q9UQ84
- UniProtKB/TrEMBL
-
A8K5H6
- Conserved Domains (3) summary
-
- cd09908
Location:213 → 289
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 206
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 308
- fen_arch; flap structure-specific endonuclease
-
XM_047434108.1 → XP_047290064.1 exonuclease 1 isoform X2
-
XM_047434129.1 → XP_047290085.1 exonuclease 1 isoform X3
-
XM_047434155.1 → XP_047290111.1 exonuclease 1 isoform X4
-
XM_006711840.3 → XP_006711903.1 exonuclease 1 isoform X1
See identical proteins and their annotated locations for XP_006711903.1
- UniProtKB/Swiss-Prot
- O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0, Q9UQ84
- UniProtKB/TrEMBL
-
A8K5H6
- Conserved Domains (3) summary
-
- cd09908
Location:213 → 289
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 206
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 308
- fen_arch; flap structure-specific endonuclease
-
XM_011544323.3 → XP_011542625.1 exonuclease 1 isoform X2
See identical proteins and their annotated locations for XP_011542625.1
- UniProtKB/TrEMBL
-
A8K5H6
- Conserved Domains (3) summary
-
- cd09908
Location:213 → 289
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 206
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 308
- fen_arch; flap structure-specific endonuclease
-
XM_011544324.3 → XP_011542626.1 exonuclease 1 isoform X3
- UniProtKB/TrEMBL
-
A8K5H6
- Conserved Domains (3) summary
-
- cd09908
Location:173 → 249
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 166
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 268
- fen_arch; flap structure-specific endonuclease
-
XM_047434139.1 → XP_047290095.1 exonuclease 1 isoform X4
-
XM_047434107.1 → XP_047290063.1 exonuclease 1 isoform X2
-
XM_047434121.1 → XP_047290077.1 exonuclease 1 isoform X3
-
XM_047434150.1 → XP_047290106.1 exonuclease 1 isoform X4
-
XM_011544321.3 → XP_011542623.1 exonuclease 1 isoform X1
See identical proteins and their annotated locations for XP_011542623.1
- UniProtKB/Swiss-Prot
- O60545, O75214, O75466, Q5T396, Q96IJ1, Q9UG38, Q9UNW0, Q9UQ84
- UniProtKB/TrEMBL
-
A8K5H6
- Conserved Domains (3) summary
-
- cd09908
Location:213 → 289
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 206
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 308
- fen_arch; flap structure-specific endonuclease
-
XM_017002793.3 → XP_016858282.1 exonuclease 1 isoform X3
- UniProtKB/TrEMBL
-
A8K5H6
- Conserved Domains (3) summary
-
- cd09908
Location:173 → 249
- H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
- cd09857
Location:1 → 166
- PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
- TIGR03674
Location:1 → 268
- fen_arch; flap structure-specific endonuclease
-
XM_047434130.1 → XP_047290086.1 exonuclease 1 isoform X4
-
XM_011544325.2 → XP_011542627.1 exonuclease 1 isoform X5
-
XM_047434160.1 → XP_047290116.1 exonuclease 1 isoform X6
Alternate T2T-CHM13v2.0
Genomic
-
NC_060925.1 Alternate T2T-CHM13v2.0
- Range
-
241253764..241301952
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054339575.1 → XP_054195550.1 exonuclease 1 isoform X1
-
XM_054339581.1 → XP_054195556.1 exonuclease 1 isoform X2
-
XM_054339577.1 → XP_054195552.1 exonuclease 1 isoform X1
-
XM_054339576.1 → XP_054195551.1 exonuclease 1 isoform X1
-
XM_054339580.1 → XP_054195555.1 exonuclease 1 isoform X2
-
XM_054339585.1 → XP_054195560.1 exonuclease 1 isoform X3
-
XM_054339589.1 → XP_054195564.1 exonuclease 1 isoform X4
-
XM_054339573.1 → XP_054195548.1 exonuclease 1 isoform X1
-
XM_054339578.1 → XP_054195553.1 exonuclease 1 isoform X2
-
XM_054339583.1 → XP_054195558.1 exonuclease 1 isoform X3
-
XM_054339587.1 → XP_054195562.1 exonuclease 1 isoform X4
-
XM_054339579.1 → XP_054195554.1 exonuclease 1 isoform X2
-
XM_054339584.1 → XP_054195559.1 exonuclease 1 isoform X3
-
XM_054339588.1 → XP_054195563.1 exonuclease 1 isoform X4
-
XM_054339574.1 → XP_054195549.1 exonuclease 1 isoform X1
-
XM_054339582.1 → XP_054195557.1 exonuclease 1 isoform X3
-
XM_054339586.1 → XP_054195561.1 exonuclease 1 isoform X4
-
XM_054339590.1 → XP_054195565.1 exonuclease 1 isoform X5
-
XM_054339591.1 → XP_054195566.1 exonuclease 1 isoform X6