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    IL1RL2 interleukin 1 receptor like 2 [ Homo sapiens (human) ]

    Gene ID: 8808, updated on 17-Jun-2024

    Summary

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    Official Symbol
    IL1RL2provided by HGNC
    Official Full Name
    interleukin 1 receptor like 2provided by HGNC
    Primary source
    HGNC:HGNC:5999
    See related
    Ensembl:ENSG00000115598 MIM:604512; AllianceGenome:HGNC:5999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL-36R; IL1RRP2; IL-1Rrp2; IL1R-rp2
    Summary
    The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 3.4), esophagus (RPKM 1.6) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL1RL2 in Genome Data Viewer
    Location:
    2q12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (102186973..102243086)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (102645259..102701349)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102803433..102856462)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102657879-102659078 Neighboring gene uncharacterized LOC107985926 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:102674234-102674816 Neighboring gene interleukin 1 receptor type 1 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:102775959-102776153 Neighboring gene IL1R1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102803139-102803668 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:102813537-102814736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851302-102851802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102851803-102852303 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:102854175-102855374 Neighboring gene Sharpr-MPRA regulatory region 14071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:102867123-102867716 Neighboring gene CFAP144 pseudogene 2 Neighboring gene interleukin 1 receptor like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications. Manzanares-Meza LD, et al. J Interferon Cytokine Res, 2022 Feb. PMID 35171706
    2. IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose-dependently activated via IL-36β and induces CD4+ lymphocyte proliferation. Penha R, et al. Cytokine, 2016 Sep. PMID 27269181
    3. Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs and facilitates DC maturation by IL-1F8 and IL-1F9. Mutamba S, et al. Eur J Immunol, 2012 Mar. PMID 22144259
    4. Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement. Sullivan GP, et al. Sci Immunol, 2022 Dec 23. PMID 36525507
    5. Altered expression of IL36γ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung's disease. Tomuschat C, et al. Pediatr Surg Int, 2017 Feb. PMID 27853811

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.
      Title: Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.
    2. In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex.
      Title: In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex.
    3. Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis.
      Title: Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis.
    4. Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement.
      Title: Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement.
    5. Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications.
      Title: Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications.
    6. Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation.
      Title: Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation.
    7. Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor.
      Title: IL-36γ has proinflammatory effects on human endothelial cells.
    8. All human blood lymphocytes express IL-36R.
      Title: IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose-dependently activated via IL-36β and induces CD4+ lymphocyte proliferation.
    9. The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention.
      Title: IL-36α expression is elevated in ulcerative colitis and promotes colonic inflammation.
    10. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP.
      Title: Structural and Functional Attributes of the Interleukin-36 Receptor.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
    EBI GWAS Catalog
    Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1 receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables interleukin-1, type I, activating receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-1-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor-like 2
    Names
    IL-1 receptor-related protein 2
    IL-36 receptor
    interleukin-1 receptor-related protein 2
    NP_001338375.1
    NP_001338376.1
    NP_001338377.1
    NP_001338378.1
    NP_001338379.1
    NP_003845.2
    XP_006712885.1
    XP_011510393.2
    XP_011510394.2
    XP_011510395.2
    XP_011510396.1
    XP_011510398.2
    XP_016860663.2
    XP_047302120.1
    XP_047302121.1
    XP_047302122.1
    XP_054200322.1
    XP_054200323.1
    XP_054200324.1
    XP_054200325.1
    XP_054200326.1
    XP_054200327.1
    XP_054200328.1
    XP_054200329.1
    XP_054200330.1
    XP_054200331.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351446.2 → NP_001338375.1  interleukin-1 receptor-like 2 isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variant 1, encodes the longest isoform (a).
      Source sequence(s)
      AC007248, AK315334, BC107064, CA448166
      Consensus CDS
      CCDS2056.1
      UniProtKB/Swiss-Prot
      A4FU63, Q13525, Q45H74, Q53TU8, Q587I8, Q9HB29
      UniProtKB/TrEMBL
      B2RCY7
      Conserved Domains (3) summary
      pfam01582
      Location:386 → 536
      TIR; TIR domain
      cd05757
      Location:130 → 218
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cl11960
      Location:26 → 112
      Ig; Immunoglobulin domain

    2. NM_001351447.1 → NP_001338376.1  interleukin-1 receptor-like 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform b.
      Source sequence(s)
      AC007271, AF284434, BC107064, CA448166
      Consensus CDS
      CCDS86867.1
      Related
      ENSP00000413348.2, ENST00000441515.3
      Conserved Domains (2) summary
      pfam01582
      Location:268 → 418
      TIR; TIR domain
      cl11960
      Location:46 → 100
      Ig; Immunoglobulin domain

    3. NM_001351448.1 → NP_001338377.1  interleukin-1 receptor-like 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform c.
      Source sequence(s)
      AC007248, AC007271
      Conserved Domains (2) summary
      pfam01582
      Location:244 → 394
      TIR; TIR domain
      cl11960
      Location:46 → 99
      Ig; Immunoglobulin domain

    4. NM_001351449.2 → NP_001338378.1  interleukin-1 receptor-like 2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform d.
      Source sequence(s)
      AC007248, AC007271
      Conserved Domains (2) summary
      pfam01582
      Location:235 → 385
      TIR; TIR domain
      cl11960
      Location:11 → 67
      Ig; Immunoglobulin domain

    5. NM_001351450.2 → NP_001338379.1  interleukin-1 receptor-like 2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 5, encodes isoform d.
      Source sequence(s)
      AC007248, AC007271
      Conserved Domains (2) summary
      pfam01582
      Location:235 → 385
      TIR; TIR domain
      cl11960
      Location:11 → 67
      Ig; Immunoglobulin domain

    6. NM_003854.4 → NP_003845.2  interleukin-1 receptor-like 2 isoform a precursor

      See identical proteins and their annotated locations for NP_003845.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variant 2, encodes the longest isoform (a).
      Source sequence(s)
      AF284434, BC107064, CA448166
      Consensus CDS
      CCDS2056.1
      UniProtKB/Swiss-Prot
      A4FU63, Q13525, Q45H74, Q53TU8, Q587I8, Q9HB29
      UniProtKB/TrEMBL
      B2RCY7
      Related
      ENSP00000264257.2, ENST00000264257.7
      Conserved Domains (3) summary
      pfam01582
      Location:386 → 536
      TIR; TIR domain
      cd05757
      Location:130 → 218
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      cl11960
      Location:26 → 112
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      102186973..102243086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005174.3 → XP_016860663.2  interleukin-1 receptor-like 2 isoform X3

      UniProtKB/TrEMBL
      B2RCY7

    2. XM_011512096.2 → XP_011510398.2  interleukin-1 receptor-like 2 isoform X7

      UniProtKB/TrEMBL
      B2RCY7

    3. XM_011512091.2 → XP_011510393.2  interleukin-1 receptor-like 2 isoform X1

      UniProtKB/TrEMBL
      B2RCY7

    4. XM_011512093.2 → XP_011510395.2  interleukin-1 receptor-like 2 isoform X4

      UniProtKB/TrEMBL
      B2RCY7

    5. XM_047446165.1 → XP_047302121.1  interleukin-1 receptor-like 2 isoform X6

      UniProtKB/TrEMBL
      B2RCY7

    6. XM_011512092.2 → XP_011510394.2  interleukin-1 receptor-like 2 isoform X2

      UniProtKB/TrEMBL
      B2RCY7

    7. XM_011512094.2 → XP_011510396.1  interleukin-1 receptor-like 2 isoform X5

      See identical proteins and their annotated locations for XP_011510396.1

      UniProtKB/TrEMBL
      B2RCY7
      Conserved Domains (4) summary
      cd05757
      Location:130 → 218
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:40 → 112
      IG_like; Immunoglobulin like
      pfam01582
      Location:386 → 536
      TIR; TIR domain
      cl11960
      Location:26 → 112
      Ig; Immunoglobulin domain

    8. XM_047446164.1 → XP_047302120.1  interleukin-1 receptor-like 2 isoform X1

      UniProtKB/TrEMBL
      B2RCY7

    9. XM_006712822.4 → XP_006712885.1  interleukin-1 receptor-like 2 isoform X8

      Conserved Domains (2) summary
      pfam01582
      Location:235 → 385
      TIR; TIR domain
      cl11960
      Location:11 → 67
      Ig; Immunoglobulin domain

    10. XM_047446166.1 → XP_047302122.1  interleukin-1 receptor-like 2 isoform X9

    RNA

    1. XR_923053.3 RNA Sequence

    2. XR_007083521.1 RNA Sequence

    3. XR_007083520.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      102645259..102701349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344349.1 → XP_054200324.1  interleukin-1 receptor-like 2 isoform X3

      UniProtKB/TrEMBL
      B2RCY7

    2. XM_054344354.1 → XP_054200329.1  interleukin-1 receptor-like 2 isoform X7

      UniProtKB/TrEMBL
      B2RCY7

    3. XM_054344347.1 → XP_054200322.1  interleukin-1 receptor-like 2 isoform X1

      UniProtKB/TrEMBL
      B2RCY7

    4. XM_054344350.1 → XP_054200325.1  interleukin-1 receptor-like 2 isoform X4

      UniProtKB/TrEMBL
      B2RCY7

    5. XM_054344353.1 → XP_054200328.1  interleukin-1 receptor-like 2 isoform X6

      UniProtKB/TrEMBL
      B2RCY7

    6. XM_054344348.1 → XP_054200323.1  interleukin-1 receptor-like 2 isoform X2

      UniProtKB/TrEMBL
      B2RCY7

    7. XM_054344351.1 → XP_054200326.1  interleukin-1 receptor-like 2 isoform X5

      UniProtKB/TrEMBL
      B2RCY7

    8. XM_054344352.1 → XP_054200327.1  interleukin-1 receptor-like 2 isoform X1

      UniProtKB/TrEMBL
      B2RCY7

    9. XM_054344355.1 → XP_054200330.1  interleukin-1 receptor-like 2 isoform X8

    10. XM_054344356.1 → XP_054200331.1  interleukin-1 receptor-like 2 isoform X9

    RNA

    1. XR_008486578.1 RNA Sequence

    2. XR_008486577.1 RNA Sequence

    3. XR_008486576.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HB29.2 GenPept UniProtKB/Swiss-Prot:Q9HB29

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