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    MARCO macrophage receptor with collagenous structure [ Homo sapiens (human) ]

    Gene ID: 8685, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MARCOprovided by HGNC
    Official Full Name
    macrophage receptor with collagenous structureprovided by HGNC
    Primary source
    HGNC:HGNC:6895
    See related
    Ensembl:ENSG00000019169 MIM:604870; AllianceGenome:HGNC:6895
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SR-A6; SCARA2
    Summary
    The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in lung (RPKM 74.5), appendix (RPKM 41.8) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MARCO in Genome Data Viewer
    Location:
    2q14.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (118942194..118994660)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (119375479..119427929)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (119699770..119752236)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119590580-119591348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119599819-119600399 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:119602243-119602892 and GRCh37_chr2:119602893-119603542 Neighboring gene long intergenic non-protein coding RNA 1956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119607811-119608363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119610971-119611506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119615003-119615764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119615765-119616526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119616527-119617286 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11898 Neighboring gene engrailed homeobox 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:119671170-119672369 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:119711468-119712667 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119746563-119747064 Neighboring gene uncharacterized LOC124906072 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:119749973-119751172 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:119807422-119808621 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:119843263-119843429 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:119868745-119869944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119870527-119871192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119891922-119892422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:119892423-119892923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:119914695-119915505 Neighboring gene RNA, 7SL, cytoplasmic 468, pseudogene Neighboring gene complement C1q like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genetic variants in MARCO are associated with the susceptibility to pulmonary tuberculosis in Chinese Han population. Ma MJ, et al. PLoS One, 2011. PMID 21886847, Free PMC Article
    2. A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function. Novakowski KE, et al. Immunol Cell Biol, 2016 Aug. PMID 26888252, Free PMC Article
    3. DNA Microarray Analysis of Submandibular Glands in IgG4-Related Disease Indicates a Role for MARCO and Other Innate Immune-Related Proteins. Ohta M, et al. Medicine (Baltimore), 2016 Feb. PMID 26886650, Free PMC Article
    4. Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression. Gu C, et al. J Immunol, 2023 Jul 1. PMID 37212598
    5. Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma. Sun H, et al. J Gastroenterol Hepatol, 2017 May. PMID 27806438

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression.
      Title: Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression.
    2. Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics.
      Title: Association of the MARCO polymorphism rs6761637 with hepatocellular carcinoma susceptibility and clinical characteristics.
    3. TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
      Title: TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain.
    4. Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.
      Title: Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.
    5. Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.
      Title: Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.
    6. Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.
      Title: Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures.
    7. Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.
      Title: Genetic Susceptibility to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants.
    8. Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.
      Title: Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function.
    9. Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
      Title: Scavenger receptor MARCO contributes to cellular internalization of exosomes by dynamin-dependent endocytosis and macropinocytosis.
    10. MARCO is involved in hepatocellular carcinoma (HCC)progression and it can be defined as a novel probable biomarker as well as treatment target for HCC.
      Title: Down-regulation of MARCO associates with tumor progression in hepatocellular carcinoma.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr potentiates the stimulation of macrophage receptor with collagenous structure by glucocorticoids via the glucocorticoid receptor pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables amyloid-beta binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cargo receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pattern recognition receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amyloid-beta clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic cell clearance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    macrophage receptor MARCO
    Names
    scavenger receptor class A, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006770.4 → NP_006761.1  macrophage receptor MARCO

      See identical proteins and their annotated locations for NP_006761.1

      Status: REVIEWED

      Source sequence(s)
      AC013457
      Consensus CDS
      CCDS2124.1
      UniProtKB/Swiss-Prot
      B4DW79, Q9UEW3, Q9Y5S3
      UniProtKB/TrEMBL
      B4DLJ6, Q4ZG40
      Related
      ENSP00000318916.4, ENST00000327097.5
      Conserved Domains (2) summary
      pfam01391
      Location:286 → 344
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:424 → 519
      SR; Scavenger receptor Cys-rich

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      118942194..118994660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512082.3 → XP_011510384.1  macrophage receptor MARCO isoform X1

      See identical proteins and their annotated locations for XP_011510384.1

      UniProtKB/Swiss-Prot
      B4DW79, Q9UEW3, Q9Y5S3
      UniProtKB/TrEMBL
      B4DLJ6, Q4ZG40
      Conserved Domains (2) summary
      pfam01391
      Location:286 → 344
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:424 → 519
      SR; Scavenger receptor Cys-rich

    2. XM_011512083.4 → XP_011510385.1  macrophage receptor MARCO isoform X2

      Conserved Domains (3) summary
      pfam01391
      Location:165 → 223
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:303 → 398
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:308 → 398
      SRCR; Scavenger receptor cysteine-rich domain

    3. XM_017005171.3 → XP_016860660.1  macrophage receptor MARCO isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      119375479..119427929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344329.1 → XP_054200304.1  macrophage receptor MARCO isoform X1

      UniProtKB/Swiss-Prot
      B4DW79, Q9UEW3, Q9Y5S3
      UniProtKB/TrEMBL
      Q4ZG40

    2. XM_054344330.1 → XP_054200305.1  macrophage receptor MARCO isoform X2

    3. XM_054344331.1 → XP_054200306.1  macrophage receptor MARCO isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UEW3.1 GenPept UniProtKB/Swiss-Prot:Q9UEW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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