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    GAI GRAS family transcription factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838057, updated on 11-Oct-2024

    Summary

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    Official Symbol
    GAI
    Official Full Name
    GRAS family transcription factor family protein
    Primary source
    TAIR:AT1G14920
    Locus tag
    AT1G14920
    See related
    Araport:AT1G14920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F10B6.34; F10B6_34; GAI PROTEIN; GIBBERELLIC ACID INSENSITIVE; RESTORATION ON GROWTH ON AMMONIA 2; RGA2
    Summary
    Similar to a putative transcription factor and transcriptional coactivators. Repressor of GA responses and involved in gibberellic acid mediated signaling. Member of the DELLA proteins that restrain the cell proliferation and expansion that drives plant growth. The protein undergoes degradation in response to GA via the 26S proteasome. GAI may be involved in reducing ROS accumulation in response to stress by up-regulating the transcription of superoxide dismutases. Represses GA-induced vegetative growth and floral initiation. Rapidly degraded in response to GA.
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    Genomic context

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    See GAI in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (5148982..5151415)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ENTH/ANTH/VHS superfamily protein Neighboring gene ncRNA Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DELLA proteins and their interacting RING Finger proteins repress gibberellin responses by binding to the promoters of a subset of gibberellin-responsive genes in Arabidopsis. Park J, et al. Plant Cell, 2013 Mar. PMID 23482857, Free PMC Article
    2. Sequence and characterization of two Arabidopsis thaliana cDNAs isolated by functional complementation of a yeast gln3 gdh1 mutant. Truong HN, et al. FEBS Lett, 1997 Jun 30. PMID 9237632
    3. Expression of Arabidopsis GAI in transgenic rice represses multiple gibberellin responses. Fu X, et al. Plant Cell, 2001 Aug. PMID 11487693, Free PMC Article
    4. Molecular and physiological characterization of arabidopsis GAI alleles obtained in targeted Ds-tagging experiments. Peng J, et al. Planta, 2002 Feb. PMID 11925042
    5. Evidence that the Arabidopsis nuclear gibberellin signalling protein GAI is not destabilised by gibberellin. Fleck B, et al. Plant J, 2002 Dec. PMID 12492836

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation activates master growth regulator DELLA by promoting histone H2A binding at chromatin in Arabidopsis.
      Title: Phosphorylation activates master growth regulator DELLA by promoting histone H2A binding at chromatin in Arabidopsis.
    2. C-TERMINAL DOMAIN PHOSPHATASE-LIKE 3 contributes to GA-mediated growth and flowering by interaction with DELLA proteins.
      Title: C-TERMINAL DOMAIN PHOSPHATASE-LIKE 3 contributes to GA-mediated growth and flowering by interaction with DELLA proteins.
    3. SMAX1 interacts with DELLA protein to inhibit seed germination under weak light conditions via gibberellin biosynthesis in Arabidopsis.
      Title: SMAX1 interacts with DELLA protein to inhibit seed germination under weak light conditions via gibberellin biosynthesis in Arabidopsis.
    4. DELLA-GAF1 complex is involved in tissue-specific expression and gibberellin feedback regulation of GA20ox1 in Arabidopsis.
      Title: DELLA-GAF1 complex is involved in tissue-specific expression and gibberellin feedback regulation of GA20ox1 in Arabidopsis.
    5. Light contributes to salt resistance through GAI protein regulation in Arabidopsis thaliana.
      Title: Light contributes to salt resistance through GAI protein regulation in Arabidopsis thaliana.
    6. Basal stomatal aperture is regulated by GA-DELLAs in Arabidopsis.
      Title: Basal stomatal aperture is regulated by GA-DELLAs in Arabidopsis.
    7. DELLA and EDS1 Form a Feedback Regulatory Module to Fine-Tune Plant Growth-Defense Tradeoff in Arabidopsis
      Title: DELLA and EDS1 Form a Feedback Regulatory Module to Fine-Tune Plant Growth-Defense Tradeoff in Arabidopsis.
    8. DELLA negatively regulates TOC159 protein abundance under low gibberellic acid. The direct DELLA-TOC159 interaction promotes TOC159 degradation by the ubiquitin/proteasome system.
      Title: Chloroplast Biogenesis Controlled by DELLA-TOC159 Interaction in Early Plant Development.
    9. the promotion by constitutive overexpression of KNAT1 of fiber formation and the expression of genes required for fiber differentiation were still reverted by DELLA accumulation, in agreement with post-translational regulation of KNAT1 by DELLA proteins.
      Title: Regulation of xylem fiber differentiation by gibberellins through DELLA-KNAT1 interaction.
    10. GAI negatively regulate dark-induced senescence and chlorophyll degradation.
      Title: DELLA proteins negatively regulate dark-induced senescence and chlorophyll degradation in Arabidopsis through interaction with the transcription factor WRKY6.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101361.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gibberellic acid homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gibberellic acid mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic salinity response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gibberellic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gibberellic acid mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of seed germination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gibberellic acid mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of nitrogen utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of seed dormancy process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of seed dormancy process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of seed germination IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of seed germination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gibberellin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within salicylic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GRAS family transcription factor family protein
    NP_172945.1
    • GIBBERELLIC ACID INSENSITIVE (GAI); CONTAINS InterPro DOMAIN/s: Transcriptional factor DELLA, N-terminal (InterPro:IPR021914), Transcription factor GRAS (InterPro:IPR005202); BEST Arabidopsis thaliana protein match is: GRAS family transcription factor family protein (TAIR:AT2G01570.1); Has 2718 Blast hits to 2657 proteins in 311 species: Archae - 0; Bacteria - 4; Metazoa - 0; Fungi - 0; Plants - 2714; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      5148982..5151415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101361.3 → NP_172945.1  GRAS family transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23643, O23724, Q9LQT8
      UniProtKB/TrEMBL
      A0A178W7K2, A0A5S9UFM6
      Conserved Domains (2) summary
      pfam03514
      Location:169 → 529
      GRAS; GRAS domain family
      pfam12041
      Location:28 → 94
      DELLA; Transcriptional regulator DELLA protein N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LQT8.1

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