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    H3-7 H3.7 histone (putative) [ Homo sapiens (human) ]

    Gene ID: 440686, updated on 17-Jun-2024

    Summary

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    Official Symbol
    H3-7provided by HGNC
    Official Full Name
    H3.7 histone (putative)provided by HGNC
    Primary source
    HGNC:HGNC:32060
    See related
    Ensembl:ENSG00000273213 AllianceGenome:HGNC:32060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p06; H3-2; H3.7; HIST2H3PS2
    Summary
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is a member of the H3 family, but is found outside of the histone cluster. There is evidence that it is transcribed and has an intact CDS, but residue changes in the protein suggest that it may be on its way to becoming a psuedogene. [provided by RefSeq, Aug 2019]
    Orthologs
    all
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    Genomic context

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    See H3-7 in Genome Data Viewer
    Location:
    1q21.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (143902386..143905977, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (142974405..142977996, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (149396962..149400553, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Arg (anticodon CCT) 7-1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:149362195-149362753 Neighboring gene H2B histone pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1255 Neighboring gene Fc gamma receptor Ic, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:149396107-149396742 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:149398885-149399385 Neighboring gene uncharacterized LOC105371209 Neighboring gene ribosomal protein L22 pseudogene 5 Neighboring gene family with sequence similarity 72 member C Neighboring gene SLIT-ROBO Rho GTPase activating protein 2D (pseudogene)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Crystal Structure and Characterization of Novel Human Histone H3 Variants, H3.6, H3.7, and H3.8. Taguchi H, et al. Biochemistry, 2017 Apr 25. PMID 28374988
    2. Modifications of human histone H3 variants during mitosis. Garcia BA, et al. Biochemistry, 2005 Oct 4. PMID 16185088
    3. Human spleen histone H3. Isolation and amino acid sequence. Ohe Y, et al. J Biochem, 1981 Oct. PMID 7309716
    4. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Huyen Y, et al. Nature, 2004 Nov 18. PMID 15525939
    5. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. Miao F, et al. Mol Endocrinol, 2006 Jul. PMID 16497732

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC126031

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone H3-7
    Names
    H3.2 histone (putative)
    histone 2, H3, pseudogene 2
    histone H3.2
    histone HIST2H3PS2
    histone cluster 2 H3 pseudogene 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355409.3 → NP_001342338.1  histone H3-7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents a spliced variant and is thought to represent a minor form.
      Source sequence(s)
      AC239798
      Consensus CDS
      CCDS30842.1
      UniProtKB/Swiss-Prot
      Q5TEC6
      UniProtKB/TrEMBL
      A8K4Y7, B2R6Y1
      Related
      ENSP00000499501.1, ENST00000609879.2
      Conserved Domains (1) summary
      PTZ00018
      Location:1 → 136
      PTZ00018; histone H3; Provisional

    2. NM_001372105.2 → NP_001359034.1  histone H3-7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents an intronless transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC239798
      Consensus CDS
      CCDS30842.1
      UniProtKB/Swiss-Prot
      Q5TEC6
      UniProtKB/TrEMBL
      A8K4Y7, B2R6Y1
      Related
      ENSP00000476960.1, ENST00000392948.5
      Conserved Domains (1) summary
      PTZ00018
      Location:1 → 136
      PTZ00018; histone H3; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      143902386..143905977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      142974405..142977996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_012783.2: Suppressed sequence

      Description
      NG_012783.2: This RefSeq was removed because it is now thought that this locus is a transcribed gene.

    2. NM_001025303.1: Suppressed sequence

      Description
      NM_001025303.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TEC6.1 GenPept UniProtKB/Swiss-Prot:Q5TEC6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials