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    IFIT3 interferon induced protein with tetratricopeptide repeats 3 [ Homo sapiens (human) ]

    Gene ID: 3437, updated on 3-Nov-2024

    Summary

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    Official Symbol
    IFIT3provided by HGNC
    Official Full Name
    interferon induced protein with tetratricopeptide repeats 3provided by HGNC
    Primary source
    HGNC:HGNC:5411
    See related
    Ensembl:ENSG00000119917 MIM:604650; AllianceGenome:HGNC:5411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49
    Summary
    Enables identical protein binding activity. Involved in antiviral innate immune response; negative regulation of apoptotic process; and negative regulation of cell population proliferation. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 22.6), lung (RPKM 21.1) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See IFIT3 in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (89327997..89340968)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (90211865..90224839)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (91087754..91100725)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902477 Neighboring gene uncharacterized LOC105378419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3739 Neighboring gene interferon induced protein with tetratricopeptide repeats 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3741 Neighboring gene uncharacterized LOC101926887 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2592 Neighboring gene Sharpr-MPRA regulatory region 6014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3746 Neighboring gene interferon induced protein with tetratricopeptide repeats 6, pseudogene Neighboring gene interferon induced protein with tetratricopeptide repeats 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular "pseudoinflammation" contributing to an aggressive phenotype. Niess H, et al. Oncotarget, 2015 Feb 20. PMID 25650658, Free PMC Article
    2. Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells. Imaizumi T, et al. J Neuroimmunol, 2018 Nov 15. PMID 30195920
    3. Association of Abnormal Elevations in IFIT3 With Overactive Cyclic GMP-AMP Synthase/Stimulator of Interferon Genes Signaling in Human Systemic Lupus Erythematosus Monocytes. Wang J, et al. Arthritis Rheumatol, 2018 Dec. PMID 29806091
    4. Down-regulation of IFIT3 protects liver from ischemia-reperfusion injury. Guan G, et al. Int Immunopharmacol, 2018 Jul. PMID 29734133
    5. Elevated interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) is a poor prognostic marker in pancreatic ductal adenocarcinoma. Zhao Y, et al. J Cancer Res Clin Oncol, 2017 Jun. PMID 28210844

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of ISG60 is induced by TLR3 signaling in BEAS-2B bronchial epithelial cells: Possible involvement in CXCL10 expression.
      Title: Expression of ISG60 is induced by TLR3 signaling in BEAS‑2B bronchial epithelial cells: Possible involvement in CXCL10 expression.
    2. IFIT3 accelerates the progression of head and neck squamous cell carcinoma by targeting PD-L1 to activate PI3K/AKT signaling pathway.
      Title: IFIT3 accelerates the progression of head and neck squamous cell carcinoma by targeting PD-L1 to activate PI3K/AKT signaling pathway.
    3. NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
      Title: NMI promotes tumor progression and gemcitabine resistance in pancreatic cancer via STAT3-IFIT3 axis.
    4. ETV7 promotes colorectal cancer progression through upregulation of IFIT3.
      Title: ETV7 promotes colorectal cancer progression through upregulation of IFIT3.
    5. Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.
      Title: Lysyl oxidase-like 2 promotes stemness and enhances antitumor effects of gefitinib in head and neck cancer via IFIT1 and IFIT3.
    6. IFIT3 Is Increased in Serum from Patients with Chronic Hepatitis B Virus (HBV) Infection and Promotes the Anti-HBV Effect of Interferon Alpha via JAK-STAT2 In Vitro.
      Title: IFIT3 Is Increased in Serum from Patients with Chronic Hepatitis B Virus (HBV) Infection and Promotes the Anti-HBV Effect of Interferon Alpha via JAK-STAT2 In Vitro.
    7. Evaluation of IFIT3 and ORM1 as Biomarkers for Discriminating Active Tuberculosis from Latent Infection.
      Title: Evaluation of IFIT3 and ORM1 as Biomarkers for Discriminating Active Tuberculosis from Latent Infection.
    8. Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma.
      Title: Comprehensive analysis of the prognosis and biological significance for IFIT family in skin cutaneous melanoma.
    9. Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression.
      Title: Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression.
    10. Retinoic Acid-Induced Gene G(RIG-G) as a Novel Monitoring Biomarker in Leukemia and Its Clinical Applications.
      Title: Retinoic Acid-Induced Gene G(RIG-G) as a Novel Monitoring Biomarker in Leukemia and Its Clinical Applications.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3; IFIT4) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFIT4, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    Vif vif HIV-1 Vif downregulates the expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3/4) in Vif-expression T cells PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of IFIT3 in human monocyte-derived dendritic cells PubMed
    Vpu vpu The expression of IFIT3 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon-induced protein with tetratricopeptide repeats 3
    Names
    CIG49
    IFI-60K
    IFIT-3
    IFIT-4
    ISG-60
    interferon-induced 60 kDa protein
    interferon-induced protein with tetratricopeptide repeats 4
    retinoic acid-induced gene G protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031683.4 → NP_001026853.1  interferon-induced protein with tetratricopeptide repeats 3 isoform a

      See identical proteins and their annotated locations for NP_001026853.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. Variants 1 and 2 both encode isoform a, using different start codons but encoding identical proteins.
      Source sequence(s)
      AL353751, BC001383, BM790031, DB268497
      Consensus CDS
      CCDS31241.1
      UniProtKB/Swiss-Prot
      O14879, Q99634, Q9BSK7
      UniProtKB/TrEMBL
      A0A7P0T855, Q5T765
      Related
      ENSP00000360876.4, ENST00000371811.4
      Conserved Domains (4) summary
      PRK02603
      Location:184 → 341
      PRK02603; photosystem I assembly protein Ycf3; Provisional
      sd00006
      Location:206 → 236
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:51 → 126
      TPR_12; Tetratricopeptide repeat
      pfam14559
      Location:150 → 213
      TPR_19; Tetratricopeptide repeat

    2. NM_001289758.2 → NP_001276687.1  interferon-induced protein with tetratricopeptide repeats 3 isoform b

      See identical proteins and their annotated locations for NP_001276687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon compared to variant 1. The resulting isoform (b) uses a translation initiation site at a downstream AUG that results in an isoform (b) with a shorter N-terminus compared to isoform 1. Variants 3 and 4 both encode the same isoform (b).
      Source sequence(s)
      AL353751, BM790031, DA673951
      Consensus CDS
      CCDS91298.1
      UniProtKB/TrEMBL
      A0A7P0T7D6, A0A7P0T855
      Related
      ENSP00000505695.1, ENST00000681277.1
      Conserved Domains (3) summary
      PRK02603
      Location:132 → 289
      PRK02603; photosystem I assembly protein Ycf3; Provisional
      sd00006
      Location:154 → 184
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1 → 74
      TPR_12; Tetratricopeptide repeat

    3. NM_001289759.2 → NP_001276688.1  interferon-induced protein with tetratricopeptide repeats 3 isoform b

      See identical proteins and their annotated locations for NP_001276688.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate exon compared to variant 1. The resulting isoform (b) uses a translation initiation site at a downstream AUG that results in an isoform (b) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL353751, BM790031, BU509201, DB268497
      Consensus CDS
      CCDS91298.1
      UniProtKB/TrEMBL
      A0A7P0T7D6, A0A7P0T855
      Related
      ENSP00000506557.1, ENST00000680037.1
      Conserved Domains (3) summary
      PRK02603
      Location:132 → 289
      PRK02603; photosystem I assembly protein Ycf3; Provisional
      sd00006
      Location:154 → 184
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1 → 74
      TPR_12; Tetratricopeptide repeat

    4. NM_001549.6 → NP_001540.2  interferon-induced protein with tetratricopeptide repeats 3 isoform a

      See identical proteins and their annotated locations for NP_001540.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1 and 2 both encode isoform a, using different start codons but encoding identical proteins.
      Source sequence(s)
      AK290427, AL353751, BM790031
      Consensus CDS
      CCDS7402.1
      UniProtKB/Swiss-Prot
      O14879, Q99634, Q9BSK7
      UniProtKB/TrEMBL
      A0A7P0T855, Q5T765
      Related
      ENSP00000360883.4, ENST00000371818.9
      Conserved Domains (4) summary
      PRK02603
      Location:184 → 341
      PRK02603; photosystem I assembly protein Ycf3; Provisional
      sd00006
      Location:206 → 236
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:51 → 126
      TPR_12; Tetratricopeptide repeat
      pfam14559
      Location:150 → 213
      TPR_19; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      89327997..89340968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      90211865..90224839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14879.1 GenPept UniProtKB/Swiss-Prot:O14879

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