GAK cyclin G associated kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: GAKprovided by HGNC
Official Full Name: cyclin G associated kinaseprovided by HGNC
Primary source: HGNC:HGNC:4113
See related: Ensembl:ENSG00000178950 MIM:602052; AllianceGenome:HGNC:4113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DNAJ26; DNAJC26
Summary: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Expression: Ubiquitous expression in testis (RPKM 16.1), colon (RPKM 15.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p16.3

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (849277..932316, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (847030..930388, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (843065..926104, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
Title: GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort.
Title: Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort.
Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
Title: Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.
Title: Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.
These findings indicate that the abnormal mitoses seen after silencing OIP5-AS1 were caused by an untimely rise in GAK levels and suggest that OIP5-AS1 suppresses cell proliferation at least in part by reducing GAK levels.
Title: LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis.
that the multiple single nucleotide polymorphisms of GAK synergistically participate in the pathogenesis of sporadic Parkinson's disease through multiple pathways.
Title: The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.
We have demonstrated that siRNA-mediated GAK silencing causes marked cell cycle disruption resulting in a raised sub-G1 alongside decreased G1 and G2/M cell cycle phases. Dual FBXW7-GAK inhibition increases multipolar mitoses
Title: RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.
GAK gene expression is increased in Parkinson disease
Title: The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane.
These results suggest that the c-Src_GAK_MCM axis plays an important role in cell cycle progression through control of the DNA replication licensing system.
Title: GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase.
We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005).
Title: Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genomewide association study for susceptibility genes contributing to familial Parkinson disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
retropepsin	gag-pol	HIV-1 PR is identified to have a physical interaction with cyclin G associated kinase (GAK) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:483844

GAK__6772 (e-PCR)
- UniSTS:466196

GDB:434012 (e-PCR)
- UniSTS:157204

L17705 (e-PCR)
- UniSTS:66091

sY3084 (e-PCR)
- UniSTS:515126

NoName (e-PCR)
- UniSTS:482675

SHGC-145680 (e-PCR)
- UniSTS:174723

WI-20233 (e-PCR)
- UniSTS:57018

SHGC-68043 (e-PCR)
- UniSTS:53741

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	ISS Inferred from Sequence or Structural Similarity more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein-folding chaperone binding	TAS Traceable Author Statement more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone cofactor-dependent protein refolding	TAS Traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in clathrin coat assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin coat disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of clathrin coat assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle uncoating	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in membrane	HDA more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin-G-associated kinase

Names: auxilin-2; dnaJ homolog subfamily C member 26

NP_001305063.1

EC 2.7.11.1

NP_005246.2

EC 2.7.11.1

XP_005272325.1

EC 2.7.11.1

XP_005272327.1

EC 2.7.11.1

XP_011511727.1

EC 2.7.11.1

XP_011511728.1

EC 2.7.11.1

XP_011511729.1

EC 2.7.11.1

XP_011511730.1

EC 2.7.11.1

XP_011511731.1

EC 2.7.11.1

XP_011511732.1

EC 2.7.11.1

XP_011511733.1

EC 2.7.11.1

XP_011511734.1

EC 2.7.11.1

XP_011511736.1

EC 2.7.11.1

XP_016863480.1

EC 2.7.11.1

XP_016863481.1

EC 2.7.11.1

XP_016863482.1

EC 2.7.11.1

XP_016863483.1

EC 2.7.11.1

XP_047305958.1

EC 2.7.11.1

XP_047305959.1

EC 2.7.11.1

XP_047305960.1

EC 2.7.11.1

XP_047305961.1

EC 2.7.11.1

XP_047305962.1

EC 2.7.11.1

XP_047305963.1

EC 2.7.11.1

XP_047305964.1

EC 2.7.11.1

XP_047305966.1

EC 2.7.11.1

XP_047305967.1

EC 2.7.11.1

XP_047305968.1

EC 2.7.11.1

XP_047305969.1

EC 2.7.11.1

XP_047305970.1

EC 2.7.11.1

XP_047305971.1

EC 2.7.11.1

XP_047305972.1

EC 2.7.11.1

XP_047305974.1

EC 2.7.11.1

XP_047305975.1

EC 2.7.11.1

XP_047305976.1

EC 2.7.11.1

XP_047305977.1

EC 2.7.11.1

XP_047305978.1

EC 2.7.11.1

XP_047305979.1

EC 2.7.11.1

XP_047305980.1

EC 2.7.11.1

XP_047305981.1

EC 2.7.11.1

XP_047305982.1

EC 2.7.11.1

XP_047305984.1

EC 2.7.11.1

XP_047305985.1

EC 2.7.11.1

XP_047305986.1

EC 2.7.11.1

XP_047305987.1

EC 2.7.11.1

XP_047305988.1

EC 2.7.11.1

XP_047305989.1

EC 2.7.11.1

XP_047305990.1

EC 2.7.11.1

XP_047305991.1

EC 2.7.11.1

XP_054205549.1

EC 2.7.11.1

XP_054205550.1

EC 2.7.11.1

XP_054205551.1

EC 2.7.11.1

XP_054205552.1

EC 2.7.11.1

XP_054205553.1

EC 2.7.11.1

XP_054205554.1

EC 2.7.11.1

XP_054205555.1

EC 2.7.11.1

XP_054205556.1

EC 2.7.11.1

XP_054205557.1

EC 2.7.11.1

XP_054205558.1

EC 2.7.11.1

XP_054205559.1

EC 2.7.11.1

XP_054205560.1

EC 2.7.11.1

XP_054205561.1

EC 2.7.11.1

XP_054205562.1

EC 2.7.11.1

XP_054205563.1

EC 2.7.11.1

XP_054205564.1

EC 2.7.11.1

XP_054205565.1

EC 2.7.11.1

XP_054205566.1

EC 2.7.11.1

XP_054205567.1

EC 2.7.11.1

XP_054205568.1

EC 2.7.11.1

XP_054205569.1

EC 2.7.11.1

XP_054205570.1

EC 2.7.11.1

XP_054205571.1

EC 2.7.11.1

XP_054205572.1

EC 2.7.11.1

XP_054205573.1

EC 2.7.11.1

XP_054205574.1

EC 2.7.11.1

XP_054205575.1

EC 2.7.11.1

XP_054205576.1

EC 2.7.11.1

XP_054205577.1

EC 2.7.11.1

XP_054205578.1

EC 2.7.11.1

XP_054205579.1

EC 2.7.11.1

XP_054205580.1

EC 2.7.11.1

XP_054205581.1

EC 2.7.11.1

XP_054205582.1

EC 2.7.11.1

XP_054205583.1

EC 2.7.11.1

XP_054205584.1

EC 2.7.11.1

XP_054205585.1

EC 2.7.11.1

XP_054205586.1

EC 2.7.11.1

XP_054205587.1

EC 2.7.11.1

XP_054205588.1

EC 2.7.11.1

XP_054205589.1

EC 2.7.11.1

XP_054205590.1

EC 2.7.11.1

XP_054205591.1

EC 2.7.11.1

XP_054205592.1

EC 2.7.11.1

XP_054205593.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001318134.2 → NP_001305063.1 cyclin-G-associated kinase isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks three consecutive exons in the 5' coding region but maintains the same reading frame as variant 1. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1.

Source sequence(s)

AA287110, AI138676, AK299554, BC000816, BC085005

Consensus CDS

CCDS82902.1

UniProtKB/TrEMBL

B4DS37

Related

ENSP00000421361.1, ENST00000511163.5

Conserved Domains (4) summary

cd06257
Location:1181 → 1225

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:53 → 230

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:491 → 629

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:46 → 241

PKc_like; Protein Kinases, catalytic domain
NM_005255.4 → NP_005246.2 cyclin-G-associated kinase isoform 1

See identical proteins and their annotated locations for NP_005246.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA287110, AI138676, BC000816, D88435, DA680073

Consensus CDS

CCDS3340.1

UniProtKB/Swiss-Prot

O14976, Q5U4P5, Q9BVY6

UniProtKB/TrEMBL

B4DS37

Related

ENSP00000314499.4, ENST00000314167.9

Conserved Domains (4) summary

cd06257
Location:1260 → 1304

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:41 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14036
Location:39 → 320

STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase

pfam10409
Location:570 → 708

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

849277..932316 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047450032.1 → XP_047305988.1 cyclin-G-associated kinase isoform X41
XM_047450022.1 → XP_047305978.1 cyclin-G-associated kinase isoform X32
XM_047450019.1 → XP_047305975.1 cyclin-G-associated kinase isoform X28
XM_017007992.2 → XP_016863481.1 cyclin-G-associated kinase isoform X17

UniProtKB/TrEMBL

B4DS37
XM_047450028.1 → XP_047305984.1 cyclin-G-associated kinase isoform X37
XM_047450024.1 → XP_047305980.1 cyclin-G-associated kinase isoform X34
XM_047450025.1 → XP_047305981.1 cyclin-G-associated kinase isoform X35
XM_047450031.1 → XP_047305987.1 cyclin-G-associated kinase isoform X40
XM_047450015.1 → XP_047305971.1 cyclin-G-associated kinase isoform X24
XM_047450004.1 → XP_047305960.1 cyclin-G-associated kinase isoform X12
XM_047450021.1 → XP_047305977.1 cyclin-G-associated kinase isoform X31
XM_047450029.1 → XP_047305985.1 cyclin-G-associated kinase isoform X38
XM_011513430.2 → XP_011511732.1 cyclin-G-associated kinase isoform X8

UniProtKB/TrEMBL

B4DS37

Conserved Domains (4) summary

cd06257
Location:1225 → 1269

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:53 → 230

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:491 → 629

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:46 → 241

PKc_like; Protein Kinases, catalytic domain
XM_011513434.3 → XP_011511736.1 cyclin-G-associated kinase isoform X26

UniProtKB/TrEMBL

Q59HA5

Conserved Domains (4) summary

cd06257
Location:1168 → 1212

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:1 → 173

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:434 → 572

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:1 → 184

PKc_like; Protein Kinases, catalytic domain
XM_047450030.1 → XP_047305986.1 cyclin-G-associated kinase isoform X39
XM_047450012.1 → XP_047305968.1 cyclin-G-associated kinase isoform X21
XM_047450002.1 → XP_047305958.1 cyclin-G-associated kinase isoform X10
XM_047450010.1 → XP_047305966.1 cyclin-G-associated kinase isoform X18
XM_017007991.2 → XP_016863480.1 cyclin-G-associated kinase isoform X7

UniProtKB/TrEMBL

B4DS37
XM_011513427.3 → XP_011511729.1 cyclin-G-associated kinase isoform X3

UniProtKB/TrEMBL

B4DS37

Conserved Domains (4) summary

cd06257
Location:1274 → 1318

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:41 → 279

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:540 → 678

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:39 → 290

PKc_like; Protein Kinases, catalytic domain
XM_047450018.1 → XP_047305974.1 cyclin-G-associated kinase isoform X27
XM_047450026.1 → XP_047305982.1 cyclin-G-associated kinase isoform X36
XM_047450007.1 → XP_047305963.1 cyclin-G-associated kinase isoform X15
XM_047450014.1 → XP_047305970.1 cyclin-G-associated kinase isoform X23
XM_047450023.1 → XP_047305979.1 cyclin-G-associated kinase isoform X33
XM_047450005.1 → XP_047305961.1 cyclin-G-associated kinase isoform X13
XM_011513428.3 → XP_011511730.1 cyclin-G-associated kinase isoform X4

UniProtKB/TrEMBL

B4DS37

Conserved Domains (4) summary

cd06257
Location:1255 → 1299

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:41 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14036
Location:39 → 320

STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase

pfam10409
Location:570 → 708

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
XM_047450006.1 → XP_047305962.1 cyclin-G-associated kinase isoform X14
XM_047450013.1 → XP_047305969.1 cyclin-G-associated kinase isoform X22
XM_005272268.3 → XP_005272325.1 cyclin-G-associated kinase isoform X5

UniProtKB/TrEMBL

Q59HA5

Conserved Domains (4) summary

cd06257
Location:1249 → 1293

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:41 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14036
Location:39 → 320

STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase

pfam10409
Location:570 → 708

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
XM_011513426.3 → XP_011511728.1 cyclin-G-associated kinase isoform X2

UniProtKB/TrEMBL

Q59HA5

Conserved Domains (4) summary

cd06257
Location:1293 → 1337

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:41 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14036
Location:39 → 320

STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase

pfam10409
Location:570 → 708

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
XM_011513431.3 → XP_011511733.1 cyclin-G-associated kinase isoform X9

UniProtKB/TrEMBL

B4DS37

Conserved Domains (4) summary

cd06257
Location:1221 → 1265

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:41 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14036
Location:39 → 320

STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase

pfam10409
Location:570 → 708

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
XM_005272270.3 → XP_005272327.1 cyclin-G-associated kinase isoform X20

UniProtKB/TrEMBL

B4DS37

Conserved Domains (4) summary

cd06257
Location:1185 → 1229

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:41 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14036
Location:39 → 320

STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase

pfam10409
Location:570 → 708

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
XM_011513425.3 → XP_011511727.1 cyclin-G-associated kinase isoform X1

UniProtKB/TrEMBL

B4DS37

Conserved Domains (4) summary

cd06257
Location:1304 → 1348

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:41 → 309

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14036
Location:39 → 320

STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase

pfam10409
Location:570 → 708

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
XM_017007993.2 → XP_016863482.1 cyclin-G-associated kinase isoform X26

UniProtKB/TrEMBL

Q59HA5

Conserved Domains (4) summary

cd06257
Location:1168 → 1212

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:1 → 173

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:434 → 572

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:1 → 184

PKc_like; Protein Kinases, catalytic domain
XM_011513432.3 → XP_011511734.1 cyclin-G-associated kinase isoform X11

UniProtKB/TrEMBL

Q59HA5

Conserved Domains (4) summary

cd06257
Location:1216 → 1260

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:1 → 221

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:482 → 620

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:1 → 232

PKc_like; Protein Kinases, catalytic domain
XM_047450020.1 → XP_047305976.1 cyclin-G-associated kinase isoform X29
XM_047450003.1 → XP_047305959.1 cyclin-G-associated kinase isoform X11
XM_047450016.1 → XP_047305972.1 cyclin-G-associated kinase isoform X25
XM_011513429.3 → XP_011511731.1 cyclin-G-associated kinase isoform X6

UniProtKB/TrEMBL

Q59HA5

Conserved Domains (4) summary

cd06257
Location:1242 → 1286

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

smart00220
Location:24 → 247

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam10409
Location:508 → 646

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl21453
Location:25 → 258

PKc_like; Protein Kinases, catalytic domain
XM_047450011.1 → XP_047305967.1 cyclin-G-associated kinase isoform X19
XM_047450008.1 → XP_047305964.1 cyclin-G-associated kinase isoform X16
XM_047450034.1 → XP_047305990.1 cyclin-G-associated kinase isoform X42
XM_047450035.1 → XP_047305991.1 cyclin-G-associated kinase isoform X43
XM_047450033.1 → XP_047305989.1 cyclin-G-associated kinase isoform X42
XM_017007994.2 → XP_016863483.1 cyclin-G-associated kinase isoform X30

UniProtKB/TrEMBL

B4DS37

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

847030..930388 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054349615.1 → XP_054205590.1 cyclin-G-associated kinase isoform X41
XM_054349606.1 → XP_054205581.1 cyclin-G-associated kinase isoform X32
XM_054349602.1 → XP_054205577.1 cyclin-G-associated kinase isoform X28
XM_054349590.1 → XP_054205565.1 cyclin-G-associated kinase isoform X17
XM_054349611.1 → XP_054205586.1 cyclin-G-associated kinase isoform X37
XM_054349608.1 → XP_054205583.1 cyclin-G-associated kinase isoform X34
XM_054349609.1 → XP_054205584.1 cyclin-G-associated kinase isoform X35
XM_054349614.1 → XP_054205589.1 cyclin-G-associated kinase isoform X40
XM_054349597.1 → XP_054205572.1 cyclin-G-associated kinase isoform X24
XM_054349585.1 → XP_054205560.1 cyclin-G-associated kinase isoform X12
XM_054349605.1 → XP_054205580.1 cyclin-G-associated kinase isoform X31
XM_054349612.1 → XP_054205587.1 cyclin-G-associated kinase isoform X38
XM_054349581.1 → XP_054205556.1 cyclin-G-associated kinase isoform X8
XM_054349600.1 → XP_054205575.1 cyclin-G-associated kinase isoform X26
XM_054349613.1 → XP_054205588.1 cyclin-G-associated kinase isoform X39
XM_054349594.1 → XP_054205569.1 cyclin-G-associated kinase isoform X21
XM_054349583.1 → XP_054205558.1 cyclin-G-associated kinase isoform X10
XM_054349591.1 → XP_054205566.1 cyclin-G-associated kinase isoform X18
XM_054349580.1 → XP_054205555.1 cyclin-G-associated kinase isoform X7
XM_054349576.1 → XP_054205551.1 cyclin-G-associated kinase isoform X3
XM_054349601.1 → XP_054205576.1 cyclin-G-associated kinase isoform X27
XM_054349610.1 → XP_054205585.1 cyclin-G-associated kinase isoform X36
XM_054349588.1 → XP_054205563.1 cyclin-G-associated kinase isoform X15
XM_054349596.1 → XP_054205571.1 cyclin-G-associated kinase isoform X23
XM_054349607.1 → XP_054205582.1 cyclin-G-associated kinase isoform X33
XM_054349586.1 → XP_054205561.1 cyclin-G-associated kinase isoform X13
XM_054349577.1 → XP_054205552.1 cyclin-G-associated kinase isoform X4
XM_054349587.1 → XP_054205562.1 cyclin-G-associated kinase isoform X14
XM_054349595.1 → XP_054205570.1 cyclin-G-associated kinase isoform X22
XM_054349578.1 → XP_054205553.1 cyclin-G-associated kinase isoform X5
XM_054349575.1 → XP_054205550.1 cyclin-G-associated kinase isoform X2
XM_054349582.1 → XP_054205557.1 cyclin-G-associated kinase isoform X9
XM_054349593.1 → XP_054205568.1 cyclin-G-associated kinase isoform X20
XM_054349574.1 → XP_054205549.1 cyclin-G-associated kinase isoform X1
XM_054349599.1 → XP_054205574.1 cyclin-G-associated kinase isoform X26
XM_054349584.1 → XP_054205559.1 cyclin-G-associated kinase isoform X11
XM_054349603.1 → XP_054205578.1 cyclin-G-associated kinase isoform X29
XM_054349598.1 → XP_054205573.1 cyclin-G-associated kinase isoform X25
XM_054349579.1 → XP_054205554.1 cyclin-G-associated kinase isoform X6
XM_054349592.1 → XP_054205567.1 cyclin-G-associated kinase isoform X19
XM_054349589.1 → XP_054205564.1 cyclin-G-associated kinase isoform X16
XM_054349617.1 → XP_054205592.1 cyclin-G-associated kinase isoform X42
XM_054349618.1 → XP_054205593.1 cyclin-G-associated kinase isoform X43
XM_054349616.1 → XP_054205591.1 cyclin-G-associated kinase isoform X42
XM_054349604.1 → XP_054205579.1 cyclin-G-associated kinase isoform X30

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001286833.1: Suppressed sequence

Description

NM_001286833.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.