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    DAPK1 death associated protein kinase 1 [ Homo sapiens (human) ]

    Gene ID: 1612, updated on 14-Nov-2024

    Summary

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    Official Symbol
    DAPK1provided by HGNC
    Official Full Name
    death associated protein kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:2674
    See related
    Ensembl:ENSG00000196730 MIM:600831; AllianceGenome:HGNC:2674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAPK; ROCO3
    Summary
    Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in lung (RPKM 19.2), ovary (RPKM 16.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DAPK1 in Genome Data Viewer
    Location:
    9q21.33
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (87497228..87708634)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (99650695..99862240)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (90112143..90323549)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376127 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:90001899-90002782 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90017019-90017636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90017637-90018252 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:90020422-90020972 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene hESC enhancers GRCh37_chr9:90024569-90025224 and GRCh37_chr9:90025225-90025878 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90025879-90026532 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:90031115-90031768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20001 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:90113131-90113888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28520 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:90145230-90146212 Neighboring gene ribosomal protein S29 pseudogene 18 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108388 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108397 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90178705-90179204 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108408 Neighboring gene DAPK1 intronic transcript 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_108410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90186048-90186548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90207629-90208129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:90215267-90215860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90234560-90235060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:90249751-90250336 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:90308876-90309094 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:90314444-90315643 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:90317453-90318652 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:90328302-90329501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28523 Neighboring gene CTSL promoter region Neighboring gene CTSL 3' regulatory element Neighboring gene EIF3J pseudogene 3 Neighboring gene cathepsin L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Specific downregulation of death-associated protein kinase enhances Fas-mediated apoptosis in the human differentiated endometrial adenocarcinoma cell line, HHUA. Tanaka T, et al. Eur J Gynaecol Oncol, 2011. PMID 21797120
    2. Biochemical and functional characterization of the ROC domain of DAPK establishes a new paradigm of GTP regulation in ROCO proteins. Bialik S, et al. Biochem Soc Trans, 2012 Oct. PMID 22988864
    3. DAPK1 is associated with FTD and not with Alzheimer's disease. Tedde A, et al. J Alzheimers Dis, 2012. PMID 22785394
    4. Impaired death-associated protein kinase-mediated survival signals in 5-fluorouracil-resistant human endometrial adenocarcinoma cells. Tanaka T, et al. Oncol Rep, 2012 Jul. PMID 22552543
    5. [Death-associated protein kinase promoter (DAPK) hypermethylation in uterine cervical cancer and intraepithelial neoplasia in Uyghur nationality women]. Niyazi M, et al. Zhonghua Zhong Liu Za Zhi, 2012 Jan. PMID 22490852

    See all (289) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Death associated protein kinase 1 predicts the prognosis and the immunotherapy response of various cancers.
      Title: Death associated protein kinase 1 predicts the prognosis and the immunotherapy response of various cancers.
    2. Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular lymphoma is related to duodenal reactive lymphoid hyperplasia.
      Title: Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular lymphoma is related to duodenal reactive lymphoid hyperplasia.
    3. Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis.
      Title: Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis.
    4. The targeting of DAPK1 with miR-190a-3p promotes autophagy in trophoblast cells.
      Title: The targeting of DAPK1 with miR-190a-3p promotes autophagy in trophoblast cells.
    5. BNIP3 and DAPK1 methylation in peripheral blood leucocytes are noninvasive biomarkers for gastric cancer.
      Title: BNIP3 and DAPK1 methylation in peripheral blood leucocytes are noninvasive biomarkers for gastric cancer.
    6. Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function.
      Title: Death-associated protein kinase 1 phosphorylates MDM2 and inhibits its protein stability and function.
    7. Knockdown of DAPK1 inhibits IL-1beta-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-kappaB and NLRP3 inflammasome pathway.
      Title: Knockdown of DAPK1 inhibits IL-1β-induced inflammation and cartilage degradation in human chondrocytes by modulating the PEDF-mediated NF-κB and NLRP3 inflammasome pathway.
    8. Diagnostic value of the combination of DAPK methylation in urinary sediment and B ultrasound for recurrent urinary bladder cancer.
      Title: Diagnostic value of the combination of DAPK methylation in urinary sediment and B ultrasound for recurrent urinary bladder cancer.
    9. NMDA Receptor GluN2B Subunit Is Involved in Excitotoxicity Mediated by Death-Associated Protein Kinase 1 in Alzheimer's Disease.
      Title: NMDA Receptor GluN2B Subunit Is Involved in Excitotoxicity Mediated by Death-Associated Protein Kinase 1 in Alzheimer's Disease.
    10. MiR-191-5p Attenuates Tau Phosphorylation, Abeta Generation, and Neuronal Cell Death by Regulating Death-Associated Protein Kinase 1.
      Title: MiR-191-5p Attenuates Tau Phosphorylation, Aβ Generation, and Neuronal Cell Death by Regulating Death-Associated Protein Kinase 1.
    Submit: New GeneRIF Correction See all GeneRIFs (235)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
    EBI GWAS Catalog
    Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
    EBI GWAS Catalog
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781I035

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables syntaxin-1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to tumor cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagic cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein autophosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of NMDA receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of autophagy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of response to tumor cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DAPK1-calmodulin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    death-associated protein kinase 1
    Names
    DAP kinase 1
    NP_001275658.1
    NP_001275659.1
    NP_001275660.1
    NP_004929.2
    XP_005251814.1
    XP_016869849.1
    XP_047278842.1
    XP_047278843.1
    XP_047278844.1
    XP_054218179.1
    XP_054218180.1
    XP_054218181.1
    XP_054218182.1
    XP_054218183.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029883.1 RefSeqGene

      Range
      5027..215794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001288729.2 → NP_001275658.1  death-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001275658.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AA854055, AL160279, BC113660, BP202018, CD642694, CN347006, CX758421, DA234399, DA855348, H77515
      Consensus CDS
      CCDS43842.1
      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
      UniProtKB/TrEMBL
      B4DHI4
      Related
      ENSP00000484267.1, ENST00000622514.4
      Conserved Domains (5) summary
      PLN03192
      Location:515 → 768
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:1308 → 1393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7 → 275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412 → 442
      ANK; ANK repeat [structural motif]
      cl39094
      Location:367 → 639
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001288730.2 → NP_001275659.1  death-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001275659.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AB208871, BC113660, BC143733, DC340223, H77515
      Consensus CDS
      CCDS43842.1
      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
      UniProtKB/TrEMBL
      B4DHI4
      Related
      ENSP00000417076.1, ENST00000472284.5
      Conserved Domains (5) summary
      PLN03192
      Location:515 → 768
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:1308 → 1393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7 → 275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412 → 442
      ANK; ANK repeat [structural motif]
      cl39094
      Location:367 → 639
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_001288731.2 → NP_001275660.1  death-associated protein kinase 1

      See identical proteins and their annotated locations for NP_001275660.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AL160279, AL161787, AL591852, BC113660, H77515
      Consensus CDS
      CCDS43842.1
      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
      UniProtKB/TrEMBL
      B4DHI4
      Related
      ENSP00000350785.5, ENST00000358077.9
      Conserved Domains (5) summary
      PLN03192
      Location:515 → 768
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:1308 → 1393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7 → 275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412 → 442
      ANK; ANK repeat [structural motif]
      cl39094
      Location:367 → 639
      Ank_2; Ankyrin repeats (3 copies)

    4. NM_004938.4 → NP_004929.2  death-associated protein kinase 1

      See identical proteins and their annotated locations for NP_004929.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK295119, BC113660, BG110813, CX872304, DR002874, H77515
      Consensus CDS
      CCDS43842.1
      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8
      UniProtKB/TrEMBL
      B4DHI4
      Related
      ENSP00000386135.3, ENST00000408954.8
      Conserved Domains (5) summary
      PLN03192
      Location:515 → 768
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd08782
      Location:1308 → 1393
      Death_DAPK1; Death domain found in death-associated protein kinase 1
      cd14194
      Location:7 → 275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      sd00045
      Location:412 → 442
      ANK; ANK repeat [structural motif]
      cl39094
      Location:367 → 639
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      87497228..87708634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422887.1 → XP_047278843.1  death-associated protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8

    2. XM_047422886.1 → XP_047278842.1  death-associated protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      B7ZLD2, B7ZLE7, P53355, Q14CQ7, Q1W5W0, Q68CP8, Q6ZRZ3, Q9BTL8

    3. XM_005251757.5 → XP_005251814.1  death-associated protein kinase 1 isoform X3

      Conserved Domains (6) summary
      smart00220
      Location:13 → 275
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00204
      Location:505 → 629
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14194
      Location:7 → 275
      STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
      pfam12796
      Location:449 → 541
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:347 → 399
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:412 → 442
      ANK; ANK repeat [structural motif]

    4. XM_047422888.1 → XP_047278844.1  death-associated protein kinase 1 isoform X4

    5. XM_017014360.2 → XP_016869849.1  death-associated protein kinase 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      99650695..99862240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362205.1 → XP_054218180.1  death-associated protein kinase 1 isoform X1

    2. XM_054362204.1 → XP_054218179.1  death-associated protein kinase 1 isoform X1

    3. XM_054362207.1 → XP_054218182.1  death-associated protein kinase 1 isoform X3

    4. XM_054362208.1 → XP_054218183.1  death-associated protein kinase 1 isoform X4

    5. XM_054362206.1 → XP_054218181.1  death-associated protein kinase 1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53355.6 GenPept UniProtKB/Swiss-Prot:P53355

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