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    ADRA2B adrenoceptor alpha 2B [ Homo sapiens (human) ]

    Gene ID: 151, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ADRA2Bprovided by HGNC
    Official Full Name
    adrenoceptor alpha 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:282
    See related
    Ensembl:ENSG00000274286 MIM:104260; AllianceGenome:HGNC:282
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAME2; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR
    Summary
    This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
    Orthologs
    mouse all
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    Genomic context

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    See ADRA2B in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (96112876..96116571, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (96619491..96623187, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96778624..96782310, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 2C, pseudogene Neighboring gene glycerol-3-phosphate acyltransferase 2, mitochondrial Neighboring gene uncharacterized LOC105373494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96725007-96725917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96757989-96758504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:96774519-96775506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11747 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96798301-96798801 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96800355-96800854 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16189 Neighboring gene astacin like metalloendopeptidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11753 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:96810561-96811062 Neighboring gene dual specificity phosphatase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study. Siitonen N, et al. Diabetologia, 2004 Aug. PMID 15309292
    2. Human response to alpha2-adrenergic agonist stimulation studied in an isolated vascular bed in vivo: Biphasic influence of dose, age, gender, and receptor genotype. King D, et al. Clin Pharmacol Ther, 2005 May. PMID 15900285
    3. Alpha2B-adrenergic receptor insertion/deletion polymorphism in women with spontaneous recurrent abortions. Galazios G, et al. J Obstet Gynaecol Res, 2011 Feb. PMID 21159032
    4. Genetic variation of the α2b-adrenoceptor affects neural correlates of successful emotional memory formation. Urner M, et al. Hum Brain Mapp, 2011 Dec. PMID 21259387, Free PMC Article
    5. Variation in the alpha2B-adrenergic receptor gene (ADRA2B) and its relationship to vascular response in vivo. Muszkat M, et al. Pharmacogenet Genomics, 2005 Jun. PMID 15900214

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Beta2 ADRENERGIC RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH EARLY-ONSET AND LATE-ONSET BRONCHIAL ASTHMA.
      Title: ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Β2 ADRENERGIC RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH EARLY-ONSET AND LATE-ONSET BRONCHIAL ASTHMA.
    2. ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders.
      Title: ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders.
    3. Alpha-2 beta-adrenergic receptor (301-303 I/D) gene polymorphism in hypertension and type 2 diabetes mellitus diseases among Saudi cases in the Qassim region.
      Title: Alpha-2 beta-adrenergic receptor (301-303 I/D) gene polymorphism in hypertension and type 2 diabetes mellitus diseases among Saudi cases in the Qassim region.
    4. Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.
      Title: Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio Myoblasts.
    5. Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory.
      Title: Aging and the Combined effects of ADRA2B and CB1 deletions on Affective Working Memory.
    6. In the group of shors with arterial hypertension, high albuminuria was associated with polymorphisms of the ACE genes (OR=2.05), ADRA2B (OR=6.00),-- The primary predictors determining the development of high albuminuria among patients with arterial hypertension in both ethnic groups were genetic ones.
      Title: Interrelation of cardiovascular risk factors with high albuminury among patients with arterial hypertension living in Mountain Shoriya.
    7. this meta-analysis has established the contributions of ADRA2B to the interactions between emotion and cognition, adding to the growing literature on individual differences in attention, perception and memory.
      Title: ADRA2B deletion variant and enhanced cognitive processing of emotional information: A meta-analytical review.
    8. Study show an associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population
      Title: Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population.
    9. An exaggerated vasoconstriction response to dexmedetomidine, an alpha-2 adrenergic agonist, has been associated with deletion in the alpha-2B adrenoreceptor gene (ADRA2B deletion).
      Title: Lack of Association Between Adrenoreceptor Genotype and the Vasoconstriction Response to Dexmedetomidine.
    10. Data indicate an association of arterial stiffness and platelet alpha2B-Rs gene expression.
      Title: Increased platelet alpha(2B)-adrenergic receptor gene expression in well-controlled hypertensives: the effect of arterial stiffness.
    Submit: New GeneRIF Correction See all GeneRIFs (93)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alpha2-adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha2-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables epinephrine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables epinephrine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in activation of protein kinase B activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adrenergic receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of epinephrine secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of norepinephrine secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of norepinephrine secretion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor transactivation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of vascular associated smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    alpha-2B adrenergic receptor
    Names
    ADRA2B adrenergic, alpha-2B-, receptor
    G-protein coupled receptor
    alpha-2 adrenergic receptor subtype C2
    alpha-2-adrenergic receptor-like 1
    alpha-2B adrenoreceptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032950.1 RefSeqGene

      Range
      4579..8274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000682.7 → NP_000673.2  alpha-2B adrenergic receptor

      See identical proteins and their annotated locations for NP_000673.2

      Status: REVIEWED

      Source sequence(s)
      AC092603, BC133021
      Consensus CDS
      CCDS56129.1
      UniProtKB/Swiss-Prot
      A2RUS0, P18089, Q4TUH9, Q53RF2, Q9BZK0
      Related
      ENSP00000480573.1, ENST00000620793.2
      Conserved Domains (1) summary
      cd15321
      Location:7 → 437
      7tmA_alpha2B_AR; alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      96112876..96116571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      96619491..96623187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18089.4 GenPept UniProtKB/Swiss-Prot:P18089

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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