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    DUSP18 dual specificity phosphatase 18 [ Homo sapiens (human) ]

    Gene ID: 150290, updated on 14-Nov-2024

    Summary

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    Official Symbol
    DUSP18provided by HGNC
    Official Full Name
    dual specificity phosphatase 18provided by HGNC
    Primary source
    HGNC:HGNC:18484
    See related
    Ensembl:ENSG00000167065 MIM:611446; AllianceGenome:HGNC:18484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSP18; DUSP20; LMWDSP20
    Summary
    Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP18 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
    Expression
    Broad expression in testis (RPKM 4.3), lung (RPKM 2.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DUSP18 in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30652051..30667875, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31115603..31131414, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31048038..31063862, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:30982632-30983831 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:30987725-30988440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31002947-31003526 Neighboring gene Sharpr-MPRA regulatory region 4664 Neighboring gene pescadillo ribosomal biogenesis factor 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31030490-31031194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13614 Neighboring gene transcobalamin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31042177-31042759 Neighboring gene solute carrier family 35 member E4 Neighboring gene ribosomal protein L13a pseudogene 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18842 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13615 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13616 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:31112835-31114034 Neighboring gene oxysterol binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18844 Neighboring gene microRNA 3200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:31168653-31169152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31175847-31176347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13619 Neighboring gene Sharpr-MPRA regulatory region 14933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31206089-31206590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31217603-31218510 Neighboring gene OSBP2 intron CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18845 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:31225743-31226942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31259058-31259558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31259559-31260059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31264006-31264542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31264543-31265078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31268713-31269213 Neighboring gene uncharacterized LOC105372994

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. Jeong DG, et al. Acta Crystallogr D Biol Crystallogr, 2006 Jun. PMID 16699184
    2. Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo. Wu Q, et al. Front Biosci, 2006 Sep 1. PMID 16720344
    3. Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain. Wu Q, et al. Biochim Biophys Acta, 2003 Feb 20. PMID 12591617
    4. Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14 dephosphorylation to promote hepatocellular carcinoma cell migration and invasion. Pu J, et al. Pathol Res Pract, 2022 Sep. PMID 35841693
    5. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. Hood KL, et al. Biochem Biophys Res Commun, 2002 Nov 8. PMID 12408986

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14 dephosphorylation to promote hepatocellular carcinoma cell migration and invasion.
      Title: Hypoxia-induced HIF1A activates DUSP18-mediated MAPK14 dephosphorylation to promote hepatocellular carcinoma cell migration and invasion.
    2. JNK and DUSP18 reciprocally modulate the SUMOylation, which plays a regulatory role in the aggregation of ataxin-1.
      Title: Dual-specificity phosphatase 18 modulates the SUMOylation and aggregation of Ataxin-1.
    3. The crystal structure of human DSP18 (official symbol DUSP18) has been determined at 2.0 A resolution.
      Title: Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family.
    4. molecular cloning, base sequence and amino acid sequence
      Title: Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain.
    5. DUSP18 appears to serve an important role by regulation of SAPK/JNK pathway
      Title: Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC32658

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-threonine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 18
    Names
    low molecular weight dual specificity phosphatase 20
    NP_001291723.1
    NP_001291724.1
    NP_001291725.1
    NP_689724.3
    XP_005261425.1
    XP_011528223.1
    XP_016884116.1
    XP_016884117.1
    XP_047297114.1
    XP_047297115.1
    XP_054181114.1
    XP_054181115.1
    XP_054181116.1
    XP_054181117.1
    XP_054181118.1
    XP_054181119.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304794.2 → NP_001291723.1  dual specificity protein phosphatase 18 isoform a

      See identical proteins and their annotated locations for NP_001291723.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      AC003072, BM550612, DA378760
      Consensus CDS
      CCDS13883.1
      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0
      UniProtKB/TrEMBL
      F8VX42
      Related
      ENSP00000340795.4, ENST00000342474.4
      Conserved Domains (1) summary
      cd14573
      Location:19 → 176
      DUSP18_21; dual specificity protein phosphatases 18 and 21

    2. NM_001304795.2 → NP_001291724.1  dual specificity protein phosphatase 18 isoform a

      See identical proteins and their annotated locations for NP_001291724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      BC030987, DA378760
      Consensus CDS
      CCDS13883.1
      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0
      UniProtKB/TrEMBL
      F8VX42
      Related
      ENSP00000385463.1, ENST00000404885.5
      Conserved Domains (1) summary
      cd14573
      Location:19 → 176
      DUSP18_21; dual specificity protein phosphatases 18 and 21

    3. NM_001304796.2 → NP_001291725.1  dual specificity protein phosphatase 18 isoform b

      See identical proteins and their annotated locations for NP_001291725.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks a segment of the central coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AC003072, BC028724, DA378760
      Consensus CDS
      CCDS77667.1
      UniProtKB/TrEMBL
      F2Z2P2
      Related
      ENSP00000384946.1, ENST00000403268.1
      Conserved Domains (1) summary
      cl21483
      Location:19 → 53
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    4. NM_152511.5 → NP_689724.3  dual specificity protein phosphatase 18 isoform a

      See identical proteins and their annotated locations for NP_689724.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
      Source sequence(s)
      AC003072, AK056074
      Consensus CDS
      CCDS13883.1
      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0
      UniProtKB/TrEMBL
      F8VX42
      Related
      ENSP00000333917.3, ENST00000334679.4
      Conserved Domains (1) summary
      cd14573
      Location:19 → 176
      DUSP18_21; dual specificity protein phosphatases 18 and 21

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      30652051..30667875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028628.2 → XP_016884117.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0
      UniProtKB/TrEMBL
      F8VX42
      Conserved Domains (1) summary
      cd14573
      Location:19 → 176
      DUSP18_21; dual specificity protein phosphatases 18 and 21

    2. XM_005261368.6 → XP_005261425.1  dual specificity protein phosphatase 18 isoform X1

      See identical proteins and their annotated locations for XP_005261425.1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0
      UniProtKB/TrEMBL
      F8VX42
      Conserved Domains (1) summary
      cd14573
      Location:19 → 176
      DUSP18_21; dual specificity protein phosphatases 18 and 21

    3. XM_047441158.1 → XP_047297114.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0

    4. XM_017028627.3 → XP_016884116.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0
      UniProtKB/TrEMBL
      F8VX42
      Conserved Domains (1) summary
      cd14573
      Location:19 → 176
      DUSP18_21; dual specificity protein phosphatases 18 and 21

    5. XM_047441159.1 → XP_047297115.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0

    6. XM_011529921.4 → XP_011528223.1  dual specificity protein phosphatase 18 isoform X1

      See identical proteins and their annotated locations for XP_011528223.1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0
      UniProtKB/TrEMBL
      F8VX42
      Conserved Domains (1) summary
      cd14573
      Location:19 → 176
      DUSP18_21; dual specificity protein phosphatases 18 and 21

    RNA

    1. XR_001755171.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      31115603..31131414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325144.1 → XP_054181119.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0

    2. XM_054325140.1 → XP_054181115.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0

    3. XM_054325141.1 → XP_054181116.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0

    4. XM_054325143.1 → XP_054181118.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0

    5. XM_054325142.1 → XP_054181117.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0

    6. XM_054325139.1 → XP_054181114.1  dual specificity protein phosphatase 18 isoform X1

      UniProtKB/Swiss-Prot
      B3KPA4, Q8NEJ0

    RNA

    1. XR_008485368.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NEJ0.1 GenPept UniProtKB/Swiss-Prot:Q8NEJ0

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