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    DUSP15 dual specificity phosphatase 15 [ Homo sapiens (human) ]

    Gene ID: 128853, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DUSP15provided by HGNC
    Official Full Name
    dual specificity phosphatase 15provided by HGNC
    Primary source
    HGNC:HGNC:16236
    See related
    Ensembl:ENSG00000149599 MIM:616776; AllianceGenome:HGNC:16236
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VHY; C20orf57
    Summary
    The protein encoded by this gene has both protein-tyrosine phophatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. This protein may function in the differentiation of oligodendrocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Biased expression in testis (RPKM 10.5), kidney (RPKM 3.2) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See DUSP15 in Genome Data Viewer
    Location:
    20q11.21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (31845593..31870664, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33570201..33595274, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30435440..30458467, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30403487-30404289 Neighboring gene ATP synthase membrane subunit f pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30407643-30408184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17700 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30411041-30411568 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30411569-30412095 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30412296-30412796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30414489-30414989 Neighboring gene myosin light chain kinase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30421849-30422479 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30424845-30425692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:30432791-30433348 Neighboring gene forkhead box S1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17701 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30467121-30467620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12770 Neighboring gene tubulin tyrosine ligase like 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17702 Neighboring gene RNA, U1 small nuclear 94, pseudogene Neighboring gene Sharpr-MPRA regulatory region 918 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17704 Neighboring gene p53 and DNA damage regulated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein. Bhore N, et al. Mol Neurobiol, 2021 May. PMID 33417224
    2. Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase. Yoon TS, et al. Proteins, 2005 Nov 15. PMID 16170801
    3. Association of oligodendrocytes differentiation regulator gene DUSP15 with autism. Tian Y, et al. World J Biol Psychiatry, 2017 Mar. PMID 27223645
    4. Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder. Fang F, et al. Behav Neurol, 2021. PMID 34257739, Free PMC Article
    5. VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX. Alonso A, et al. J Biol Chem, 2004 Jul 30. PMID 15138252

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein.
      Title: Dual-Specificity Phosphatase 15 (DUSP15) Modulates Notch Signaling by Enhancing the Stability of Notch Protein.
    2. Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder.
      Title: Association between Genetic Variants in DUSP15, CNTNAP2, and PCDHA Genes and Risk of Childhood Autism Spectrum Disorder.
    3. The results showed that dual specificity phosphatase 15 (DUSP15) rs3746599 was significantly associated with autism under allelic, additive and dominant models,The findings initially suggest that DUSP15 might be a susceptibility gene for autism in Chinese Han population.
      Title: Association of oligodendrocytes differentiation regulator gene DUSP15 with autism.
    4. Dusp15/VHY is a key regulator of oligodendrocyte differentiation, and PDGFR-beta and SNX6 are novel and specific Dusp15 substrates.
      Title: Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach.
    5. VHY is a new member of a subgroup of myristoylated VH1-like small dual specificity phosphatases
      Title: VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX.
    6. crystal structure of catalytic domain
      Title: Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20645, FLJ40111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 15
    Names
    VH1-related member Y
    dual specificity phosphatase-like 15
    vaccinia virus VH1-related dual-specific protein phosphatase Y
    NP_001012662.1
    NP_001307407.1
    NP_001307408.1
    NP_542178.2
    NP_817130.1
    XP_016883143.1
    XP_016883144.1
    XP_016883145.1
    XP_016883146.1
    XP_016883147.1
    XP_016883148.1
    XP_016883149.1
    XP_016883150.1
    XP_016883151.1
    XP_047295846.1
    XP_047295847.1
    XP_054178944.1
    XP_054178945.1
    XP_054178946.1
    XP_054178947.1
    XP_054178948.1
    XP_054178949.1
    XP_054178950.1
    XP_054178951.1
    XP_054178952.1
    XP_054178953.1
    XP_054178954.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012644.3 → NP_001012662.1  dual specificity protein phosphatase 15 isoform b

      See identical proteins and their annotated locations for NP_001012662.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to isoform a. Variants 2 and 3 both encode isoform b, which has a shorter N-terminus than isoform a.
      Source sequence(s)
      AI051640, AK091960, AL732169, BC056911, BF377396, DN996690
      Consensus CDS
      CCDS42862.1
      UniProtKB/Swiss-Prot
      Q9H1R2
      Related
      ENSP00000381157.1, ENST00000398083.5
      Conserved Domains (1) summary
      cl21483
      Location:1 → 35
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. NM_001320478.1 → NP_001307407.1  dual specificity protein phosphatase 15 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (c) has a distinct, shorter N-terminus than isoform a.
      Source sequence(s)
      AI051640, AK091960, AK097430, BM554314
      Consensus CDS
      CCDS82607.1
      UniProtKB/Swiss-Prot
      Q9H1R2
      Related
      ENSP00000365133.4, ENST00000375966.8
      Conserved Domains (1) summary
      cd00127
      Location:1 → 135
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    3. NM_001320479.1 → NP_001307408.1  dual specificity protein phosphatase 15 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains multiple differences at both the 5' and 3' ends, compared to variant 1, and initiates translation at an alternate start codon. The encoded isoform (d) has distinct N- and C-termini and is longer than isoform a.
      Source sequence(s)
      AK000652, AK097430
      Consensus CDS
      CCDS82606.1
      UniProtKB/Swiss-Prot
      A6NH79, A8MVC8, Q5QP62, Q5QP63, Q5QP65, Q6PGN7, Q8N826, Q9BX24, Q9H1R2
      Related
      ENSP00000278979.3, ENST00000278979.7
      Conserved Domains (1) summary
      cl28904
      Location:5 → 142
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. NM_080611.5 → NP_542178.2  dual specificity protein phosphatase 15 isoform a

      See identical proteins and their annotated locations for NP_542178.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AL160175
      Consensus CDS
      CCDS13193.1
      UniProtKB/Swiss-Prot
      Q9H1R2
      Related
      ENSP00000341658.5, ENST00000339738.10
      Conserved Domains (1) summary
      cd00127
      Location:4 → 138
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

    5. NM_177991.3 → NP_817130.1  dual specificity protein phosphatase 15 isoform b

      See identical proteins and their annotated locations for NP_817130.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to isoform a. Variants 2 and 3 both encode isoform b, which has a shorter N-terminus than isoform a.
      Source sequence(s)
      AI051640, AK091960, BI517878, DN996690
      Consensus CDS
      CCDS42862.1
      UniProtKB/Swiss-Prot
      Q9H1R2
      Related
      ENSP00000381158.2, ENST00000398084.6
      Conserved Domains (1) summary
      cl21483
      Location:1 → 35
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      31845593..31870664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027656.2 → XP_016883145.1  dual specificity protein phosphatase 15 isoform X3

    2. XM_017027655.2 → XP_016883144.1  dual specificity protein phosphatase 15 isoform X2

    3. XM_017027657.2 → XP_016883146.1  dual specificity protein phosphatase 15 isoform X4

    4. XM_017027654.2 → XP_016883143.1  dual specificity protein phosphatase 15 isoform X1

    5. XM_017027660.2 → XP_016883149.1  dual specificity protein phosphatase 15 isoform X5

    6. XM_017027658.2 → XP_016883147.1  dual specificity protein phosphatase 15 isoform X5

    7. XM_017027659.2 → XP_016883148.1  dual specificity protein phosphatase 15 isoform X5

    8. XM_017027662.2 → XP_016883151.1  dual specificity protein phosphatase 15 isoform X5

    9. XM_017027661.2 → XP_016883150.1  dual specificity protein phosphatase 15 isoform X5

    10. XM_047439890.1 → XP_047295846.1  dual specificity protein phosphatase 15 isoform X6

    11. XM_047439891.1 → XP_047295847.1  dual specificity protein phosphatase 15 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      33570201..33595274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322971.1 → XP_054178946.1  dual specificity protein phosphatase 15 isoform X3

    2. XM_054322970.1 → XP_054178945.1  dual specificity protein phosphatase 15 isoform X2

    3. XM_054322972.1 → XP_054178947.1  dual specificity protein phosphatase 15 isoform X4

    4. XM_054322969.1 → XP_054178944.1  dual specificity protein phosphatase 15 isoform X1

    5. XM_054322974.1 → XP_054178949.1  dual specificity protein phosphatase 15 isoform X5

    6. XM_054322973.1 → XP_054178948.1  dual specificity protein phosphatase 15 isoform X5

    7. XM_054322975.1 → XP_054178950.1  dual specificity protein phosphatase 15 isoform X5

    8. XM_054322977.1 → XP_054178952.1  dual specificity protein phosphatase 15 isoform X5

    9. XM_054322976.1 → XP_054178951.1  dual specificity protein phosphatase 15 isoform X5

    10. XM_054322978.1 → XP_054178953.1  dual specificity protein phosphatase 15 isoform X6

    11. XM_054322979.1 → XP_054178954.1  dual specificity protein phosphatase 15 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H1R2.4 GenPept UniProtKB/Swiss-Prot:Q9H1R2

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