KATNA1 katanin catalytic subunit A1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KATNA1provided by HGNC
Official Full Name: katanin catalytic subunit A1provided by HGNC
Primary source: HGNC:HGNC:6216
See related: Ensembl:ENSG00000186625 MIM:606696; AllianceGenome:HGNC:6216
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
Expression: Broad expression in testis (RPKM 18.8), ovary (RPKM 7.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q25.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (149594873..149648990, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (150794606..150848774, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (149916009..149969850, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth.
Title: SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth.
Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival.
Title: Katanin P60 and P80 in papillary thyroid carcinoma patients: Indicators for exacerbated tumor features and worse disease-free survival.
Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.
Title: Katanin P60: a potential biomarker for lymph node metastasis and prognosis for non-small cell lung cancer.
A chemical genetics approach to examine the functions of AAA proteins.
Title: A chemical genetics approach to examine the functions of AAA proteins.
structures of the apo and ATPgammaS-bound states of the catalytic AAA domain of human katanin p60 at 3.0 and 2.9 A resolution, respectively, are reported.
Title: Structural and Molecular Basis for Katanin-Mediated Severing of Glutamylated Microtubules.
In this study, we identified the main regulatory region of KATNA1 gene encoding katanin-p60 as 5' UTR, which has a key role for its expression, and showed Elk1 binding to KATNA1. Furthermore, we identified that Elk1 decreased katanin-p60 and spastin protein expressions, while mRNA levels were increased upon Elk1 overexpression.
Title: Elk1 affects katanin and spastin proteins via differential transcriptional and post-transcriptional regulations.
targeting an active version of katanin p60 to the kinetochore can reduce the fidelity of achieving full chromosome alignment in metaphase and could serve as a microtubule disruption tool for the future.
Title: Creation and testing of a new, local microtubule-disruption tool based on the microtubule-severing enzyme, katanin p60.
CAMSAP3 precisely coordinates with dynein and katanin to regulate the microtubule detachment process.
Title: CAMSAP3 accumulates in the pericentrosomal area and accompanies microtubule release from the centrosome via katanin.
ASPM-katanin complex controls microtubule disassembly at spindle poles and that misregulation of this process can lead to microcephaly.
Title: Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.
Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails
Title: Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH46515 (e-PCR)
- UniSTS:75534

STS-T47614 (e-PCR)
- UniSTS:75352

SHGC-32611 (e-PCR)
- UniSTS:12888

KATNA1 (e-PCR)
- UniSTS:506468

SHGC-59927 (e-PCR)
- UniSTS:40327

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule severing ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasmic microtubule organization	NAS Non-traceable Author Statement more info	PubMed
involved_in microtubule severing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of katanin complex	IPI Inferred from Physical Interaction more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: katanin p60 ATPase-containing subunit A1

Names: katanin p60 (ATPase containing) subunit A 1; katanin p60 subunit A1; p60 katanin

NP_001191005.1

EC 5.6.1.1

NP_008975.1

EC 5.6.1.1

XP_005266861.1

EC 5.6.1.1

XP_016865696.1

EC 5.6.1.1

XP_016865699.1

EC 5.6.1.1

XP_047274067.1

EC 5.6.1.1

XP_054210071.1

EC 5.6.1.1

XP_054210072.1

EC 5.6.1.1

XP_054210073.1

EC 5.6.1.1

XP_054210074.1

EC 5.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204076.2 → NP_001191005.1 katanin p60 ATPase-containing subunit A1 isoform 2

See identical proteins and their annotated locations for NP_001191005.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

BC050428, DB031858

Consensus CDS

CCDS56456.1

UniProtKB/Swiss-Prot

O75449

Related

ENSP00000335180.8, ENST00000335643.12

Conserved Domains (1) summary

pfam00004
Location:169 → 305

AAA; ATPase family associated with various cellular activities (AAA)
NM_007044.4 → NP_008975.1 katanin p60 ATPase-containing subunit A1 isoform 1

See identical proteins and their annotated locations for NP_008975.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK292090, BC050428, CA426364

Consensus CDS

CCDS5217.1

UniProtKB/Swiss-Prot

E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52

UniProtKB/TrEMBL

A8K7S5

Related

ENSP00000356381.2, ENST00000367411.7

Conserved Domains (3) summary

smart00382
Location:241 → 382

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:245 → 381

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:456 → 489

Vps4_C; Vps4 C terminal oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

149594873..149648990 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418111.1 → XP_047274067.1 katanin p60 ATPase-containing subunit A1 isoform X2
XM_005266804.3 → XP_005266861.1 katanin p60 ATPase-containing subunit A1 isoform X1

See identical proteins and their annotated locations for XP_005266861.1

UniProtKB/Swiss-Prot

E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52

UniProtKB/TrEMBL

A8K7S5

Related

ENSP00000335106.5, ENST00000335647.9

Conserved Domains (3) summary

smart00382
Location:241 → 382

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:245 → 381

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:456 → 489

Vps4_C; Vps4 C terminal oligomerization domain
XM_017010207.3 → XP_016865696.1 katanin p60 ATPase-containing subunit A1 isoform X1

UniProtKB/Swiss-Prot

E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52

UniProtKB/TrEMBL

A8K7S5

Conserved Domains (3) summary

smart00382
Location:241 → 382

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:245 → 381

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:456 → 489

Vps4_C; Vps4 C terminal oligomerization domain
XM_017010210.3 → XP_016865699.1 katanin p60 ATPase-containing subunit A1 isoform X1

UniProtKB/Swiss-Prot

E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52

UniProtKB/TrEMBL

A8K7S5

Conserved Domains (3) summary

smart00382
Location:241 → 382

AAA; ATPases associated with a variety of cellular activities

pfam00004
Location:245 → 381

AAA; ATPase family associated with various cellular activities (AAA)

pfam09336
Location:456 → 489

Vps4_C; Vps4 C terminal oligomerization domain

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

150794606..150848774 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054354098.1 → XP_054210073.1 katanin p60 ATPase-containing subunit A1 isoform X2
XM_054354096.1 → XP_054210071.1 katanin p60 ATPase-containing subunit A1 isoform X1

UniProtKB/Swiss-Prot

E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52
XM_054354097.1 → XP_054210072.1 katanin p60 ATPase-containing subunit A1 isoform X1

UniProtKB/Swiss-Prot

E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52
XM_054354099.1 → XP_054210074.1 katanin p60 ATPase-containing subunit A1 isoform X1

UniProtKB/Swiss-Prot

E1P5A3, O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52