Structured Abstract

Contents

• Preface
• 1. Introduction
  • Burden of Suffering
  • Prior Recommendations
  • Analytic Frameworks and Key Questions
• 2. Methods
  • Literature Search Strategy
  • Inclusion/Exclusion Criteria
  • Size of Literature Reviewed
  • Data Extraction and Synthesis
• 3. Results
  • Hormone Replacement Therapy Studies
  • Meta-Analysis of HRT Studies
  • Studies of Selective Estrogen Receptor Modulators (SERMs)
• 4. Discussion
  • Conclusions
  • Limitations of the Literature
  • Future Research
• Acknowledgements
• Appendix 1a. Search Strategy for Effects of Hormone Replacement Therapy on Coagulation
• Appendix 1b. Search Strategy for Hormone Replacement Therapy Randomized Controlled Trials
• Appendix 1c. Search Strategy for Selective Estrogen Receptor Modulators (SERMs)
• Appendix 2. Hormone Replacement Therapy and Venous Thromboembolism Search Results
• Appendix 3. Criteria for Grading the Internal Validity of Individual Studies
• Appendix 4
• References

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services.¹ Contract No. 290-97-0018, Task Order No. 2, Technical Support of the U.S. Preventive Services Task Force. Prepared by: Oregon Health Sciences University Evidence-based Practice Center, Portland, Oregon.

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