Structured Abstract

Contents

• 1. INTRODUCTION
  • Purpose of Review and Prior U.S. Preventive Services Task Force Recommendation
  • Condition Definitions
  • Prevalence and Burden of Disease
  • Risk Factors
  • Natural History
  • Rationale for Screening
  • Interventions/Treatment
  • Current Clinical Practice
  • Recommendations of Other Groups
• 2. METHODS
  • Key Questions and Analytic Framework
  • Search Strategies
  • Study Selection
  • Data Abstraction and Quality Rating
  • Data Synthesis
  • External Review
• 3. RESULTS
  • Description of Randomized, Controlled Trials
  • Key Question 1 How Effective Is Screening for Lung Cancer in Reducing Mortality and Morbidity?
  • Key Question 2 What Are the Test Characteristics of Screening Tests for Lung Cancer?
  • Key Question 3 What Are the Harms Associated With Lung Cancer Screening and Are There Ways to Modify Harms?
  • Key Question 4 How Effective Is the Treatment of Surgical Resection of Early (Stage IA) Non-Small Cell Lung Cancer?
  • Key Question 5 What Are the Harms Associated With Surgical Resection of Early (Stage IA) Non-Small Cell Lung Cancer?
• 4. DISCUSSION
  • Summary of Review Findings
  • Limitations
  • Emerging Issues and Future Research
  • Conclusions
• References
• Appendix A Detailed Methods
• Appendix B Evidence Tables and Quality Tables

Acknowledgements: The authors acknowledge Andrew Hamilton, MLS, MS, for assistance with literature searches and Amanda Brunton, BS, for assistance with preparing this report. We also thank AHRQ Officers Jennifer Croswell, MD, MPH, Mary Barton, MD, MPP, Tracy Wolff, MD, MPH, and Tess Miller, DrPH, and USPSTF leads Sue Curry, PhD, Mike LeFevre, MD, MSPH, Virginia Moyer, MD, MPH, and Doug Owens, MD, MS, for their contributions to this report.

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, Contract No. HHSA-290-2007-10057-I-EPC3, Task Order No. 13. Prepared by: Pacific Northwest Evidence-based Practice Center²,

Suggested citation:

Humphrey L, Deffebach M, Pappas M, Baumann C, Artis K, Priest Mitchell J, Zakher B, Fu R, Slatore C. Screening for Lung Cancer: Systematic Review to Update the U.S. Preventive Services Task Force Recommendation. Evidence Synthesis No. 105. AHRQ Publication No. 13-05188-EF-1. Rockville, MD: Agency for Healthcare Research and Quality; 2013.

This report is based on research conducted by the Pacific Northwest Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-02-0024). The investigators involved have declared no conflicts of interest with objectively conducting this research. The findings and conclusions in this document are those of the authors, who are responsible for its content, and do not necessarily represent the views of AHRQ. No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment.

The report may be used, in whole or in part, as the basis for the development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

1

540 Gaither Road, Rockville, MD 20850; www​.ahrq.gov

2

Oregon Health & Science University, Mail Code: BICC, 3181 SW Sam Jackson Park Road, Portland, OR 97239; www​.ohsu.edu/epc