Expression profiling of malignant megakaryocytes (MK) from 6 donors with essential thrombocythemia (ET). MK derived from bone marrow CD34+ hematopoietic progenitor cells. Progenitors induced to differentiate into MK by treatment with 100 ng/ml thrombopoietin. Apoptotic pathway is impaired in ET.
GPL96:
[HG-U133A] Affymetrix Human Genome U133A Array
Citation:
Tenedini E, Fagioli ME, Vianelli N, Tazzari PL et al. Gene expression profiling of normal and malignant CD34-derived megakaryocytic cells. Blood 2004 Nov 15;104(10):3126-35. PMID: 15271793