Notch ligand delta-like 4 effect on interleukin 10-secreting T helper 1 cells
Summary:
Analysis of IL-10-secreting and -nonsecreting T helper 1 (Th1) cells stimulated with Notch ligand Delta-like 4. The Notch pathway is a major driver of IL-10 production in Th1 cells. Results provide insight into the molecular basis of Notch-mediated IL-10 induction in Th1 cells.
Neumann C, Heinrich F, Neumann K, Junghans V et al. Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med 2014 Aug 25;211(9):1807-19. PMID: 25073792
