TGF-beta receptor type 1 gene Alk5 deficiency effect on embryonic tongue bud
Summary:
Analysis of tongue bud collected from E13.5 embryos with conditional inactivation of Alk5 in cranial neural crest cells (CNCCs). The Alk5 gene encodes TGF-β type 1 receptor. Results provide insight into the role of Alk5-mediated TGF-β signaling in CNCCs on early tongue myogenesis.
Han A, Zhao H, Li J, Pelikan R et al. ALK5-mediated transforming growth factor β signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions. Mol Cell Biol 2014 Aug;34(16):3120-31. PMID: 24912677
