Transforming growth factor β effect on mammary epithelial NMuMG cells overexpressing major satellite transcripts
Summary:
Analysis of major satellite-NMuMG cells treated with TGF-β for 8 hr. Major satellites are noncoding pericentromeric transcripts essential for heterochromatin formation. Results provide insight into the role of pericentromeric transcription on TGF-β-induced epithelial-mesenchymal transition (EMT).
Millanes-Romero A, Herranz N, Perrera V, Iturbide A et al. Regulation of heterochromatin transcription by Snail1/LOXL2 during epithelial-to-mesenchymal transition. Mol Cell 2013 Dec 12;52(5):746-57. PMID: 24239292