Analysis of pancreatic islets from insulin receptor substrate 2 (Irs2) knockouts treated with anti-diabetic compound sodium tungstate for 21 days. Tungstate normalizes glucose tolerance in the Irs2 -/- animals. Results provide insight into the molecular effects of tungstate on pancreatic β-cells.
Oliveira JM, Rebuffat SA, Gasa R, Burks DJ et al. Tungstate promotes β-cell survival in Irs2-/- mice. Am J Physiol Endocrinol Metab 2014 Jan 1;306(1):E36-47. PMID: 24253047