DataSet Record GDS5373: Expression Profiles Data Analysis Tools Sample Subsets
Title: miR-221 expression effect on prostate cancer cell line
Cluster AnalysisGDS5373 Cluster Image
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Summary: Analysis of PC-3 prostate cancer cells expressing pre-miR-221. miR-221 is frequently downregulated in primary prostate cancer. Results provide insight into the role of miR-221 in the pathogenesis of prostate cancer.
Organism: Homo sapiens
Platform: GPL570: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citations:
  • Kneitz B, Krebs M, Kalogirou C, Schubert M et al. Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3. Cancer Res 2014 May 1;74(9):2591-603. PMID: 24607843
  • Krebs M, Behrmann C, Kalogirou C, Sokolakis I et al. miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1. Biomed Res Int 2019;2019:6392748. PMID: 31828111
Reference Series: GSE45627 Sample count: 4
Value type: count Series published: 2014/03/27