N-terminal truncated GATA1-mutant effect on fetal CD34+ hematopoietic stem and progenitor cells: time course
Summary:
Analysis of fetal CD34+ HSPCs expressing N-terminal truncated GATA1-mutant (GATA1s) during myeloid differentiation for 4 and 14 days. GATA1s mutations are associated with transient leukemia (TL)- in Down syndrome neonates. Results provide insight into the role of GATA1s in TL pathogenesis.
GPL6480:
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
Citation:
Maroz A, Stachorski L, Emmrich S, Reinhardt K et al. GATA1s induces hyperproliferation of eosinophil precursors in Down syndrome transient leukemia. Leukemia 2014 Jun;28(6):1259-70. PMID: 24336126
