BET inhibitor I-BET726 effect on non-MYCN-amplified neuroblastoma cell line SK-N-SH: dose response
Summary:
Analysis of SK-N-SH neuroblastoma (NB) cells treated with 0.1 or 1 uM I-BET726, a BET inhibitor. MYCN is unamplified in SK-N-SH. BET inhibitors display anti-proliferative activity in MYC driven hematologic cancer models. Results provide insight into the anti-proliferative activity of I-BET726 in NB.
Wyce A, Ganji G, Smitheman KN, Chung CW et al. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models. PLoS One 2013;8(8):e72967. PMID: 24009722
