BET inhibitor I-BET726 effect on MYCN-amplified neuroblastoma cell line CHP-212: dose response
Summary:
Analysis of CHP-212 neuroblastoma (NB) cells treated with 0.1 or 1 uM I-BET726, a BET inhibitor. MYCN is amplified in CHP-212. BET inhibitors display anti-proliferative activity in MYC driven hematologic cancer models. Results provide insight into the anti-proliferative activity of I-BET726 in NB.
Wyce A, Ganji G, Smitheman KN, Chung CW et al. BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models. PLoS One 2013;8(8):e72967. PMID: 24009722