Hydrostatic pressure-responsive genes in optic nerve head astrocytes
Summary:
Temporal analysis of how astrocytes in the optic nerve head (ONH) respond to changes in intraocular pressure (IOP). ONH astrocytes exposed to 60 mm Hg hydrostatic pressure for 6, 24, and 48 hours. Lends understanding to pathogenesis of glaucoma.
GPL8300:
[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array
Citations:
Yang P, Agapova O, Parker A, Shannon W et al. DNA microarray analysis of gene expression in human optic nerve head astrocytes in response to hydrostatic pressure. Physiol Genomics 2004 Apr 13;17(2):157-69. PMID: 14747662
Kompass KS, Agapova OA, Li W, Kaufman PL et al. Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension. BMC Neurosci 2008 Sep 26;9:93. PMID: 18822132
