Linezolid and vancomycin effect on whole blood of methicillin-resistant Staphylococcus aureus (MRSA) sepsis model: time course
Summary:
Analysis of blood from A/J males injected with S. aureus USA300 then treated intravenously with linezolid (L) or vancomycin (V) for up to 24hr. L and V represent two different classes of antibiotics. Results provide insight into the molecular effects of each antibiotic on the host in MRSA sepsis.
Sharma-Kuinkel BK, Zhang Y, Yan Q, Ahn SH et al. Host gene expression profiling and in vivo cytokine studies to characterize the role of linezolid and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) murine sepsis model. PLoS One 2013;8(4):e60463. PMID: 23565251
