Human epidermal growth factor receptor 2-positive breast cancer brain metastases
Summary:
Analysis of HER2+ breast cancer brain metastasis specimens and HER2+ nonmetastatic primary breast tumors. Samples were matched for patient age upon primary tumor detection and ER status of primary tumor. Results provide insight into the molecular basis of HER2+ breast cancer outgrowth in the brain.
McMullin RP, Wittner BS, Yang C, Denton-Schneider BR et al. A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity. Breast Cancer Res 2014 Mar 14;16(2):R25. PMID: 24625110
