Lipopolysaccharide effect on transmembrane protease, serine 6 deficient liver
Summary:
Analysis of liver from Tmprss6 knockouts (KO) and iron-deficient WT littermates treated with LPS to induce acute inflammation. Tmprss6 KOs are iron-deficient with high levels of hepcidin, a key iron regulator. Results provide insight into molecular basis of the Tmprss6 KO inflammatory response.
Riba M, Rausa M, Sorosina M, Cittaro D et al. A strong anti-inflammatory signature revealed by liver transcription profiling of Tmprss6-/- mice. PLoS One 2013;8(7):e69694. PMID: 23922777
