Dioxin exposure in utero effect on the pituitary gland at maturity
Summary:
Analysis of pituitary glands of postnatal day 70 male rats exposed in utero to dioxin at gestational day 15. Rats exposed to dioxin in utero exhibit a reduced pituitary synthesis of luteinizing hormone at the late fetal and early postnatal period, leading to defects in sexual behavior at adulthood.
Takeda T, Fujii M, Hattori Y, Yamamoto M et al. Maternal exposure to dioxin imprints sexual immaturity of the pups through fixing the status of the reduced expression of hypothalamic gonadotropin-releasing hormone. Mol Pharmacol 2014 Jan;85(1):74-82. PMID: 24132183
