Regulatory T cell ablation effect on BDC2.5/NOD pancreatic or splenic natural killer cells: time course
Summary:
Analysis of natural killer (NK) cells isolated from the pancreas or spleen of BDC2.5/NOD.Foxp3DTR animals up to 24 hours after diphtheria toxin (DT) injection to ablate regulatory T (Treg) cells. Results provide insight into molecular mechanisms underlying Treg/NK cross-talk in controlling diabetes.
Sitrin J, Ring A, Garcia KC, Benoist C et al. Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. J Exp Med 2013 Jun 3;210(6):1153-65. PMID: 23650440